کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9569522 | 1666336 | 2019 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Interaction of tetramer protein with carbon nanotubes
ترجمه فارسی عنوان
تعامل پروتئین تترامر با نانولوله های کربنی
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کلمات کلیدی
نانولوله کربنی، تعامل پروتئین-پروتئین، میکروب وابستگی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی تئوریک و عملی
چکیده انگلیسی
Carbon nanotubes can interact with proteins or enzymes upon penetration into cell membranes of living organisms that may affect the protein-protein interactions in vivo. Here, three structural models composed of four-chain esterase from Hungatella hathewayi with and without pristine or carboxylated single-walled carbon nanotube (SWCNT) are constructed to investigate the changes in protein-protein interactions and SWCNT orientations by molecular dynamics simulations. The results show that the protein-protein interact very tightly to protect them from the separation by the carboxylated or pristine SWCNTs, as shown by the calculations of binding affinity and the distances between the centers of mass of different protein chains. Both pristine and carboxylated SWCNTs cause structural changes in the esterase. In addition, functionalization (e.g., carboxylation) can regulate the SWCNT orientation when positioned near the esterase.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Surface Science - Volume 464, 15 January 2019, Pages 30-35
Journal: Applied Surface Science - Volume 464, 15 January 2019, Pages 30-35
نویسندگان
Zhuotong Zeng, Ming Chen, Jie Liang, Rong Xiao, Guangming Zeng, Jiachao Zhang, Zhifeng Liu, Anwei Chen, Yaoyu Zhou, Dan Mo,