کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9635853 | 1427493 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of the phase behaviour of the solvent-antisolvent systems on the gas-antisolvent-crystallisation of paracetamol
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موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
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چکیده انگلیسی
The influence of the phase behaviour of the solvent-antisolvent system on the process conditions for the gas-antisolvent process is investigated. The two fluids are modelled by the Peng-Robinson equation of state while the dissolved solid is described by a Clapeyron-type approach. Based on the correlation of the ternary system, a liquid-liquid immiscibility region has been found which hinders the proper crystallisation of the solute. A thorough investigation of the binary solvent-antisolvent system by the global phase diagram methods yields a criterion for the proper choice of the solvent. The crucial property turns out to be the distance of the solvent-antisolvent system from the tricritical curve in the global phase diagram.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Supercritical Fluids - Volume 33, Issue 2, February 2005, Pages 107-113
Journal: The Journal of Supercritical Fluids - Volume 33, Issue 2, February 2005, Pages 107-113
نویسندگان
A. Weber, L.V. Yelash, T. Kraska,