کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9645145 | 1433684 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Developmental and vascular risk factors for Alzheimer's disease
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
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چکیده انگلیسی
To investigate developmental and vascular risk factors for Alzheimer's disease (AD), we examined 90 incident cases of probable AD in a cohort of 1859 individuals followed prospectively for six years. The presence of the APOE-É4 allele was the strongest risk factor, and with increasing survival age, the effect of É4 diminished. Among É4 positives, developmental risk factors such as smaller head circumference (â¤54.4 cm) and having more than four children in the household at age 2-3 were independently associated with incident AD (hazard ratio (HR) = 2.6 (95% CI 1.04-6.3) and 3.3 (1.2-9.2), respectively). Among É4 negatives, vascular risk factors were related to AD risk (self-reported diagnoses of transient ischemic attack and diabetes (HR = 5.1, 95% CI 1.7-15.5; HR 3.3, 95% CI 1.4-8.1)). These findings indicate that clinical AD is a result of early life as well as later life risk factors, and that genetic predisposition to the disease may modify the constellation of predictors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 26, Issue 3, March 2005, Pages 325-334
Journal: Neurobiology of Aging - Volume 26, Issue 3, March 2005, Pages 325-334
نویسندگان
Amy R. Borenstein, Yougui Wu, James A. Mortimer, Gerard D. Schellenberg, Wayne C. McCormick, James D. Bowen, Susan McCurry, Eric B. Larson,