کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9678378 | 1454324 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Factors affecting protein release from microcapsule prepared by liposome in alginate
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موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
شیمی کلوئیدی و سطحی
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چکیده انگلیسی
A new type of drug delivery system that microcapsule was prepared by liposome in alginate on this paper, bovine serum albumin (BSA) as an model drug. Influences of liposomes composition and multivalent cations on morphology, enveloped rate, integrality and release in vitro from microcapsule were investigated. The results are showed that Ca2+ and Ba2+ made hydrogels form easier than Al3+ and particle size were uniform, circular, but microcapsule prepared by Al3+ was flat circular and easily adhere to each other. Particle size of all microcapsules was 200-300 μm after dryness, measured by vernier calliper. BSA enveloped rate prepared by PC/PG/Chol and Ba2+ was highest, 77.65%, and also correlative to concentration of lipid. At the other hand, Ba2+ microcapsule prepared by liposome in alginate has not an initial burst and have a good performance on delivering protein. Integrality of protein was not destroyed after encapsulated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces B: Biointerfaces - Volume 42, Issues 3â4, 25 May 2005, Pages 253-258
Journal: Colloids and Surfaces B: Biointerfaces - Volume 42, Issues 3â4, 25 May 2005, Pages 253-258
نویسندگان
Chuanyun Dai, Bochu Wang, Hongwei Zhao, Biao Li,