کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
96888 160474 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cardiac β1-adrenoceptor expression in two stress-induced cardiomyopathy-related deaths
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Cardiac β1-adrenoceptor expression in two stress-induced cardiomyopathy-related deaths
چکیده انگلیسی

Stress-induced cardiomyopathy (SICM) is characterized by transient systolic dysfunction of the apical and/or midventricular myocardial segments in the absence of obstructive coronary artery disease and is unique in that it can manifest itself after acute emotional stress. Excessive amounts of catecholamines released from sympathetic nerve endings as well as from the adrenal medulla under stressful conditions are considered to produce intracellular Ca2+ overload and cardiac dysfunction through the β1-adrenoceptor signal transduction pathway. We describe the clinical and pathomorphological findings in two stress-induced cardiomyopathy fatal cases. Levels of catecholamines and their metabolites in urine samples were assessed too. Morphological patterns seen in SICM result from the complex interplay between sympathetic innervations, β-receptor density and function and catecholamine sensitivity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Forensic Science International - Volume 207, Issues 1–3, 15 April 2011, Pages e8–e11
نویسندگان
, , , , , , ,