Thermodynamic properties for the system of silybin and poly(ethylene glycol) 6000

Solid dispersions of silybin and poly(ethylene glycol) (PEG) 6000 were prepared by fusion-cooling. T-wt% and ΔfusHw-wt% diagrams have been constructed by DSC method. A eutectic point with wtsily% = 33.3 and TmE = 324.3 K was determined. IR spectroscopy and X-ray diffraction results indicates that the spectrum can be regarded as the superposition of those silybin and PEG 6000. There was no significant change in the crystal structure of silybin and PEG 6000 in their solid dispersion formulations. The experimental T-wt% and ΔfusHw-wt% diagrams were fit with fair agreement by Flory-Huggins model.