کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9694126 | 1459640 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pressurization effects on the polymorphic forms of famotidine
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
جریان سیال و فرایندهای انتقال
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Pressurization effects on the polymorphic forms of famotidine Pressurization effects on the polymorphic forms of famotidine](/preview/png/9694126.png)
چکیده انگلیسی
The effects of high static pressure on the polymorphic modifications A and B of famotidine were examined by differential scanning calorimetry, infrared and Raman spectroscopy, and X-ray powder diffractometry. The obtained effects appeared to differ significantly depending on whether they were monitored by DSC or any of the other above techniques. In particular, DSC measurements tend to deceptively amplify a tendency of the pure modification B to turn into the more stable form A under pressurization, while the spectroscopic methods and XRPD exhibit no essential change in the crystal structure of the metastable form B. The apparent morphological transformation in the pressed samples stems from the nature of the DSC method itself.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Thermochimica Acta - Volume 430, Issues 1â2, June 2005, Pages 35-41
Journal: Thermochimica Acta - Volume 430, Issues 1â2, June 2005, Pages 35-41
نویسندگان
Zoltán Német, Béla Hegedűs, Csaba Jr., Janisz Sztatisz, György Pokol,