کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9723263 | 1475233 | 2005 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Transient overexpression of the 5-HT1A receptor impairs water-maze but not hole-board performance
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
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چکیده انگلیسی
Previously, we showed that mice that overexpress the 5-HT1A receptor transiently from embryonic to perinatal stages show reduced anxiety and changes in brain serotonin turnover as adults. Here, we investigated the long-term effects of the temporary overexpression of the 5-HT1A receptor during early embryonic and perinatal development on the performance in two memory tasks. In the hole-board test mice that were homozygous for the transgene showed similar behavioral habituation but increased locomotion compared to heterozygous mice. In contrast water-maze performance of homozygous mice was impaired compared to heterozygous mice. These results suggest that a transient overexpression of 5-HT1A receptor during embryonic and perinatal development has detrimental effects on water-maze performance at adult stages.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Learning and Memory - Volume 84, Issue 1, July 2005, Pages 57-68
Journal: Neurobiology of Learning and Memory - Volume 84, Issue 1, July 2005, Pages 57-68
نویسندگان
B. Bert, E. Dere, N. Wilhelmi, H. Kusserow, F. Theuring, J.P. Huston, H. Fink,