کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9723285 | 1475235 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Influence of mRNA and protein synthesis inhibitors on the long-term memory acquisition of classically conditioned earthworms
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Influence of mRNA and protein synthesis inhibitors on the long-term memory acquisition of classically conditioned earthworms Influence of mRNA and protein synthesis inhibitors on the long-term memory acquisition of classically conditioned earthworms](/preview/png/9723285.png)
چکیده انگلیسی
We investigated the process of memory consolidation following classical conditioning of earthworms. Earthworms were conditioned in paired trials by a weak vibration as a conditioned stimulus (CS), and by light as an unconditioned stimulus (US). The occurrence of a shrinking response upon exposure to the CS increased steadily with the number of paired training trials. When the training procedure was changed by increasing the intertrial interval (ITI), it was found that only those worms trained with a 68Â s ITI exhibited long-term memory retention for at least 24Â h. The influence of mRNA synthesis inhibition by actinomycin-D or of protein synthesis by anisomycin on memory consolidation was also examined. Induction of the long-term memory was blocked when either of these two compounds was injected into the body cavity of the worm within 25Â min of conditioning with the 68Â s ITI. These results demonstrate that the long-term memory is dependent upon protein synthesis in response to the upregulation of new transcription messengers.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Learning and Memory - Volume 83, Issue 2, March 2005, Pages 151-157
Journal: Neurobiology of Learning and Memory - Volume 83, Issue 2, March 2005, Pages 151-157
نویسندگان
Hikaru Watanabe, Tomohiro Takaya, Toshinobu Shimoi, Hiroto Ogawa, Yoshiichiro Kitamura, Kotaro Oka,