کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9727860 | 1480211 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Damage, connectivity and essentiality in protein-protein interaction networks
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
ریاضیات
فیزیک ریاضی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Damage, connectivity and essentiality in protein-protein interaction networks Damage, connectivity and essentiality in protein-protein interaction networks](/preview/png/9727860.png)
چکیده انگلیسی
The proteome, a set of proteins expressed in an organism, is organized in an intricate web called the protein-protein interaction (PPI) network. In this article we propose a topological parameter called damage, that measures the consequences of the deletion of a protein from the network. We investigate different PPI data sets using this parameter and also traditional ones: the connectivity and the clusterization coefficient. We show that damage histogram obeys a power law in all data sets, and that proteins that cause a large damage are, with high probability, essential. For data sets that consider physical interactions the PPI network is a hierarchical scale-free network, while for data sets that consider functional interactions the PPI network is a scale-free graph.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physica A: Statistical Mechanics and its Applications - Volume 349, Issues 3â4, 15 April 2005, Pages 675-684
Journal: Physica A: Statistical Mechanics and its Applications - Volume 349, Issues 3â4, 15 April 2005, Pages 675-684
نویسندگان
Jean Schmith, Ney Lemke, José C.M. Mombach, PatrÃcia Benelli, Cláudia K. Barcellos, Guilherme B. Bedin,