کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9728036 1480216 2005 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Motifs in gene transcription regulatory networks
موضوعات مرتبط
مهندسی و علوم پایه ریاضیات فیزیک ریاضی
پیش نمایش صفحه اول مقاله
Motifs in gene transcription regulatory networks
چکیده انگلیسی
A brief overview is given of the structure and evolution of gene transcription regulatory networks (GTRNs) of simple organisms like Escherichia coli and yeast Saccharomyces cerevisiae. A prominent motif appearing in the GTRNs is the feed forward loop (FFL). The FFLs have essential functions in gene regulatory processes and it is desirable that the operational noise of a FFL be kept at the minimum for reliability of signal transmission. We calculate the variances around the mean protein levels in the steady states of Type-1 and Type-4 coherent FFLs using a stochastic model of gene expression and the Langevin formalism. The Type-1 FFL is found to be less noisy than the Type-4 FFL. Type-1 FFL motif is more abundant than Type-4 FFL motif in GTRNs. This leads to the conjecture that noise is one of the evolvable traits on which natural selection acts.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physica A: Statistical Mechanics and its Applications - Volume 346, Issues 1–2, 1 February 2005, Pages 49-57
نویسندگان
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