کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
973638 1480120 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of tumor microenvironmental factors on tumor growth dynamics modeled by correlated colored noises with colored cross-correlation
ترجمه فارسی عنوان
اثر عوامل میکرو محیطی تومور بر پویایی رشد تومور به وسیله صداهای رنگی همبسته با همبستگی متقابل رنگی
کلمات کلیدی
معادله Langevin؛ معادله Fokker-Planck؛ سر و صدای رنگی؛ پویایی رشد تومور
موضوعات مرتبط
مهندسی و علوم پایه ریاضیات فیزیک ریاضی
چکیده انگلیسی


• Effect of non-immunogenic microenvironmental factors on tumor growth is investigated.
• The steady state distribution for the tumor growth system is derived.
• The non-immunogenic microenvironmental factors effects inhibits tumor growth.
• The strength of the correlation time ττ exerts growth effect on the tumor growth system.

The effect of non-immunogenic tumor microenvironmental factors on tumor growth dynamics modeled by correlated additive and multiplicative colored noises is investigated. Using the Novikov theorem, Fox approach and Ansatz of Hanggi, an approximate Fokker–Planck equation for the system is obtained and analytic expression for the steady state distribution Pst(x)Pst(x) is derived. Based on the numerical results, we find that fluctuations of microenvironmental factors within the tumor site with parameter θθ have a diffusive effect on the tumor growth dynamics, and the tumor response to the microenvironmental factors with parameter αα inhibits growth at weak correlation time ττ. Moreover, at increasing correlation time ττ the inhibitive effect of tumor response αα is suppressed and instead a systematic growth promotion is noticed. The result also reveals that the strength of the correlation time ττ has a strong influence on the growth effects exerted by the non-immunogenic component of tumor microenvironment on tumor growth.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physica A: Statistical Mechanics and its Applications - Volume 453, 1 July 2016, Pages 298–304
نویسندگان
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