Extrinsic periodic information interpolates between monostable and bistable states in intracellular calcium dynamics

• The role of extrinsic periodic information on intracellular calcium oscillation is studied.
• Extrinsic periodic information interpolates synchronous and anti-synchronous oscillation.
• Extrinsic periodic information interpolates bistable and monostable states of intracellular calcium oscillation.

Extrinsic periodic information including physiological cyclical and circadian replacement would affect inevitably a real cell, in this paper we investigate the effect of extrinsic periodic information on intracellular calcium dynamics by means of second-order algorithm for stochastic simulation colored noises. By simulating time evolutions and stationary probability distribution of intracellular Ca2+ concentrations, the results show: (i) intracellular calcium oscillation between cytosol and calcium store shows synchronous and anti-synchronous oscillation as intensity and frequency of extrinsic periodic information vary; (ii) extrinsic periodic information interpolates stability from bistable state →→ monostable state →→ bistable state →→ monostable state as frequency of extrinsic periodic information increases; (iii) extrinsic periodic information interpolates stability from monostable state →→ bistable state as intensity of extrinsic periodic information increases.