کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
975396 | 933028 | 2007 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Comparative analysis of the gene co-regulatory network of normal and cancerous lung
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
ریاضیات
فیزیک ریاضی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The gene co-regulatory networks of normal and cancerous lung cells are constructed based on microarrays. In these networks, nodes represent genes and links represent co-regulatory relationships between genes. A comparison of these two networks indicates that they are significantly different in terms of both global statistical features and also in some details. The results imply at least four interesting messages: First, lung cancer is not simply a disordered system since it also has some rules in itself. Second, both of these networks can be decomposed into several functional modules, each of which is responsible for certain biological function. Third, among those functional modules, the module which is responsible for immune reactions seems to work independently rather than co-operating with others. Fourth, the phenomenon of module dysfunction is observed in cancerous lung cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physica A: Statistical Mechanics and its Applications - Volume 384, Issue 2, 15 October 2007, Pages 739-746
Journal: Physica A: Statistical Mechanics and its Applications - Volume 384, Issue 2, 15 October 2007, Pages 739-746
نویسندگان
Lanfang Sun, Menghui Li, Lu Jiang, Lu Tan,