کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
976583 1480122 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
On the effusion time of drugs from the open pore of a spherical vesicle
ترجمه فارسی عنوان
درباره زمان افیوژن داروها از منافذ باز یک کیسه کروی
کلمات کلیدی
زمان انفجار؛ ثابت زمانی موثر؛ انتشار کنترل شده؛ دستگاه کروی؛ تبدیل لاپلاس؛ تابع بسل
موضوعات مرتبط
مهندسی و علوم پایه ریاضیات فیزیک ریاضی
چکیده انگلیسی


• The effusion time was calculated for a spherical device.
• An analytical solution was derived for the fraction of drug released.
• The effusion time contained geometric characteristics of the device.

Solute permeation through a spherical liposomal vesicle was analyzed using Fick’s second law and a mixed Neumann–Dirichlet boundary condition. The first-principles approach was necessary to help calculate the effusion time of a medication through a pore located on the surface of the device. An infinite series of Bessel functions represented the concentration in the Laplace domain. This method yielded closed-form expressions for the characteristic time and the Laplace-transformed fraction of drug released, which was approximated by the first term of the series. The time constant was inversely proportional to the diffusion coefficient in the system and decreased as the pore size increased. It took 4 times the effusion time to unload nearly ninety-eight percent of the pharmaceutical ingredient.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physica A: Statistical Mechanics and its Applications - Volume 451, 1 June 2016, Pages 366–372
نویسندگان
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