کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9769228 | 1501244 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and antibacterial activity of some new 1-heteroaryl-5-amino-4-phenyl-3-trifluoromethylpyrazoles
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and antibacterial activity of some new 1-heteroaryl-5-amino-4-phenyl-3-trifluoromethylpyrazoles Synthesis and antibacterial activity of some new 1-heteroaryl-5-amino-4-phenyl-3-trifluoromethylpyrazoles](/preview/png/9769228.png)
چکیده انگلیسی
Treatment of 1,1,1-trifluoromethyl-3-cyano-3-phenylpropanone (1) with several heteroarylhydrazines (2a-e) in refluxing ethanol affords 1-heteroaryl-5-amino-4-phenyl-3-trifluoromethylpyrazoles (4) in a regioselective manner. The location of trifluoromethyl group at position-3 was established by a combined use of 13C and 19F NMR spectroscopy. The reaction proceeds through the intermediacy of the hydrazone which was isolated and characterized in one case (3e) by performing the reaction at room temperature. The compounds 3e and 4 were tested for their antibacterial property against six Gram-positive and three Gram-negative bacteria. Two compounds, namely 1-(benzothiazol-2â²-yl)-5-amino-4-phenyl-3-trifluoromethylpyrazole (4a) and 1-(6â²-methylbenzothiazol-2â²-yl)-5-amino-4-phenyl-3-trifluoromethylpyrazole (4b) have displayed antibacterial activity comparable to the commercial antibiotics.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 40, Issue 9, September 2005, Pages 922-927
Journal: European Journal of Medicinal Chemistry - Volume 40, Issue 9, September 2005, Pages 922-927
نویسندگان
Vinod Kumar, Ranjana Aggarwal, Parikshit Tyagi, Shiv P. Singh,