کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
978076 | 933245 | 2007 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Modeling subspecies and the tumor-immune system interaction: Steps toward understanding therapy
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
ریاضیات
فیزیک ریاضی
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چکیده انگلیسی
A mesoscopic nutrient competition model for cancer growth is generalized to describe the growth of a heterogeneous tumor and the interactions between the tumor and the immune system. Our simulations show that the success of a mutation depends not only on its intrinsic competitive advantages, but also on its location in the tumor mass. It is also shown that the simple killing of tumor cells by immune cells, even when their activity is increased by therapy, is not sufficient to stem tumor growth, but another mechanism (such as pinning) is needed for a successful therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physica A: Statistical Mechanics and its Applications - Volume 386, Issue 2, 15 December 2007, Pages 713-719
Journal: Physica A: Statistical Mechanics and its Applications - Volume 386, Issue 2, 15 December 2007, Pages 713-719
نویسندگان
S.A. Menchón, R.A. Ramos, C.A. Condat,