کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
978931 | 933312 | 2010 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Asynchronous motion and transport of K+ in the KcsA selectivity filter
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موضوعات مرتبط
مهندسی و علوم پایه
ریاضیات
فیزیک ریاضی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A recently proposed Markovian model of K+ ion transport through the selectivity filter of the KcsA bacterial channel is generalized. This generalization allows a specific estimate to be made of the current through the channel which is found to be consistent with experimentally determined values [11.0 (+/â) 0.1 pA]. A further aspect of the generalization presented here is the quantification of the difference of synchronous vs. asynchronous motion of the K+ ions and water molecules in the channel. Considering excluded volume effects only, the difference in mean passage time through the channel is in the range 50%-75%; on the basis of calculations reported here, we argue that this difference will be even more pronounced when K+/ K+ Coulombic repulsions and electrostatic attractive interactions between K+ ions and the carbonyl groups lining the channel are taken into account.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physica A: Statistical Mechanics and its Applications - Volume 389, Issue 16, 15 August 2010, Pages 3013-3022
Journal: Physica A: Statistical Mechanics and its Applications - Volume 389, Issue 16, 15 August 2010, Pages 3013-3022
نویسندگان
K. PaweÅek, John J. Kozak, Z.J. Grzywna,