کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9818177 1518777 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
New insights into the cellular response to radiation using microbeams
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد سطوح، پوشش‌ها و فیلم‌ها
پیش نمایش صفحه اول مقاله
New insights into the cellular response to radiation using microbeams
چکیده انگلیسی
Microbeams are now being used to study a number of novel 'non-targeted' responses that do not follow the standard radiation model based on direct DNA damage and are now known to occur when living cells and tissues are irradiated. One such response is the so-called 'bystander effect' where unirradiated cells are damaged through signalling pathways initiated by a nearby irradiated cell. This effect predominates at low doses and profoundly challenges our understanding of environmental radiation risk. Furthermore, we now have evidence that simple molecules (such as nitric oxide) are involved in the signalling process, such that it may be possible to chemically influence the bystander response. If so, then this could eventually lead to improvements in the treatment of cancer by radiotherapy. Other studies have shown that the bystander effect is induced with equal effectiveness if either the nucleus or the cytoplasm of a cell is targeted.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms - Volume 231, Issues 1–4, April 2005, Pages 189-194
نویسندگان
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