کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9871635 1532132 2005 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Optimisation study of α-cyclotron production of At-211/Po-211g for high-LET metabolic radiotherapy purposes
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم تشعشع
پیش نمایش صفحه اول مقاله
Optimisation study of α-cyclotron production of At-211/Po-211g for high-LET metabolic radiotherapy purposes
چکیده انگلیسی
The production of no-carrier-added (NCA) α-emitter 211At/211gPo radionuclides for high-LET targeted radiotherapy and immunoradiotherapy, through the 209Bi(α,2n) reaction, together with the required wet radiochemistry and radioanalytical quality controls carried out at LASA is described, through dedicated irradiation experiments at the MC-40 cyclotron of JRC-Ispra. The amount of both the γ-emitter 210At and its long half-lived α-emitting daughter 210Po is optimised and minimised by appropriate choice of energy and energy loss of α particle beam. The measured excitation functions for production of the main radioisotopic impurity 210At→210Po are compared with theoretical predictions from model calculations performed at ENEA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 63, Issues 5–6, November–December 2005, Pages 621-631
نویسندگان
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