L-(methyl-11C) methionine positron emission tomography for target delineation in resected high-grade gliomas before radiotherapy

Conclusion: In operated patients with brain gliomas, the size and location of residual MET uptake differs considerably from abnormalities found on postoperative MRI. Because postoperative changes cannot be differentiated from residual tumor by MRI, MET-PET, with a greater specificity for tumor tissue, can help to outline the gross tumor volume with greater accuracy.