کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9872577 1533192 2005 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The bronchiolar epithelium as a prominent source of pro-inflammatory cytokines after lung irradiation
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم تشعشع
پیش نمایش صفحه اول مقاله
The bronchiolar epithelium as a prominent source of pro-inflammatory cytokines after lung irradiation
چکیده انگلیسی
Conclusions: In the present study we have clearly demonstrated the immediate expression of the pro-inflammatory cytokines TNF-α, IL-1α, and IL-6 in the bronchiolar epithelium in the first hours after lung irradiation. A second, long-lasting release of these cytokines by the bronchiolar and alveolar epithelium, as well as by inflammatory cells, was observed at the onset of acute pneumonitis. Therefore, we postulate that lung irradiation causes immediate epithelial reaction, with the bronchiolar epithelium becoming a significant source of pro-inflammatory cytokines capable of promoting inflammation through recruitment and activation of inflammatory cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Radiation Oncology*Biology*Physics - Volume 61, Issue 5, 1 April 2005, Pages 1482-1492
نویسندگان
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