کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9876372 | 1533549 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Consequences of intramolecular dityrosine formation on a DNA-protein complex: a molecular modeling study
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Consequences of intramolecular dityrosine formation on a DNA-protein complex: a molecular modeling study Consequences of intramolecular dityrosine formation on a DNA-protein complex: a molecular modeling study](/preview/png/9876372.png)
چکیده انگلیسی
Irradiation of the free lac repressor with γ-rays abolishes protein's ability to specifically bind operator DNA. A possible radiation-induced protein damage is a dityrosine (DTyr) formed by two spatially close radiation-induced tyrosyl radicals. We performed the molecular modeling of complexes between operator DNA and DTyr-bearing parts (headpieces) of the repressor. The presence of DTyr affects the structure and the interactions between partners. A detailed analysis allows to conclude this damage can partially account for the loss of repressor ability to bind DNA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Radiation Physics and Chemistry - Volume 72, Issues 2â3, February 2005, Pages 271-278
Journal: Radiation Physics and Chemistry - Volume 72, Issues 2â3, February 2005, Pages 271-278
نویسندگان
Julien Gras, Denise Sy, Séverine Eon, Michel Charlier, Melanie Spotheim-Maurizot,