کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9901562 | 1545426 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Preliminary assessment of carrageenan as excipient for extrusion/spheronisation
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوتکنولوژی یا زیستفناوری
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چکیده انگلیسی
The current study pursues the suitability of different types of carrageenan as a novel extrusion aid. The aim was to find out a suitable substitution to the commonly used microcrystalline cellulose (MCC). The types of κ-carrageenan were found to be the most appropriate material and the required fraction to produce acceptable pellets in the formulation was determined. The investigation showed that 5% of κ-carageenan was necessary to produce pellets without MCC. Similar formulations produced with MCC or κ-carrageenan were compared with respect to size and shape of the pellets. κ-Carrageenan required higher water content for the formation of pellets, but the formulation was more robust as the optimal range of water content was much broader. Hence, κ-Carrageenan seems to be a suitable and promising extrusion aid. The study showed that the substitution of MCC by κ-carrageenan in formulations is possible and the produced pellets were of high quality.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutics and Biopharmaceutics - Volume 59, Issue 1, January 2005, Pages 127-131
Journal: European Journal of Pharmaceutics and Biopharmaceutics - Volume 59, Issue 1, January 2005, Pages 127-131
نویسندگان
Martin Bornhöft, Markus Thommes, Peter Kleinebudde,