کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9903915 | 1546138 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Folates and antifolates in the treatment of cancer; role of folic acid supplementation on efficacy of folate and non-folate drugs
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Folates and antifolates in the treatment of cancer; role of folic acid supplementation on efficacy of folate and non-folate drugs Folates and antifolates in the treatment of cancer; role of folic acid supplementation on efficacy of folate and non-folate drugs](/preview/png/9903915.png)
چکیده انگلیسی
Folates are essential nutrients for the cell for DNA synthesis. From a nutritional perspective, a high folate status may have a beneficial/protective effect against cancer, birth defects and age-related diseases. However, data presented in this study provide evidence that a high folate status can also have a differential impact on the therapeutic efficacy of both folate-based and other widely used anticancer agents. This study describes the molecular mechanisms underlying these effects, which involve folate influx/efflux proteins, intracellular metabolism and target enzymes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Trends in Food Science & Technology - Volume 16, Issues 6â7, JuneâJuly 2005, Pages 289-297
Journal: Trends in Food Science & Technology - Volume 16, Issues 6â7, JuneâJuly 2005, Pages 289-297
نویسندگان
G.J. Peters, J.H. Hooijberg, G.J.L. Kaspers, G. Jansen,