کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9905228 1546706 2005 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
High-resolution cDNA microarray-based comparative genomic hybridization analysis in neuroblastoma
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
High-resolution cDNA microarray-based comparative genomic hybridization analysis in neuroblastoma
چکیده انگلیسی
Neuroblastoma (NB) is one of the most common pediatric solid tumors and displays a broad variety of genomic alterations. Array-based comparative genomic hybridization (A-CGH) is a novel technology enabling the high-resolution detection of DNA copy number aberrations. In this article, we outline features of this new technology and approaches of data analysis. We focus on stage specific DNA copy number variations in neuroblastoma detected by cDNA array-based comparative genomic hybridization (A-CGH). We also discuss hypothetic evolutionary models of neuroblastoma progression that can be derived from A-CGH data.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 228, Issues 1–2, 18 October 2005, Pages 71-81
نویسندگان
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