کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9905774 | 1547302 | 2005 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Prognostic and therapeutic relevance of HER2 expression in osteosarcoma and Ewing's sarcoma
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Prognostic and therapeutic relevance of HER2 expression in osteosarcoma and Ewing's sarcoma Prognostic and therapeutic relevance of HER2 expression in osteosarcoma and Ewing's sarcoma](/preview/png/9905774.png)
چکیده انگلیسی
Expression of HER2 was evaluated by immunohistochemical techniques in 84 osteosarcoma (OS) and 113 Ewing's sarcoma (ES) paraffin-embedded tumour biopsies. HER2 gene status was also assessed in a panel of cell lines as well as in vitro efficacy of trastuzumab (a humanised antibody directed against HER2) as single agent or in combination with the insulin-like growth factor I receptor (IGF-IR) IR3 antibody. Overexpression of HER2 was present in 32% of OS and 16% of ES and was significantly associated with the increased expression of P-glycoprotein, a surface molecule responsible for multidrug resistance. Event-free survival analyses revealed a prognostic value for HER2 and/or P-glycoprotein expression in OS, but not in ES. However, despite its prognostic relevance, no therapeutic effectiveness was observed pre-clinically for trastuzumab-driven therapy, in both OS or ES cell lines, unless the antibody was associated with anti-IGF-IR targeting strategies. Therefore, the therapeutic potential of trastuzumab in these neoplasms may be better exploited in combined treatments with anti-IGF-IR approaches.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Cancer - Volume 41, Issue 9, June 2005, Pages 1349-1361
Journal: European Journal of Cancer - Volume 41, Issue 9, June 2005, Pages 1349-1361
نویسندگان
Katia Scotlandi, Maria C. Manara, Claudia M. Hattinger, Stefania Benini, Stefania Perdichizzi, Michela Pasello, Gaetano Bacci, Licciana Zanella, Franco Bertoni, Piero Picci, Massimo Serra,