کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9912925 | 1550149 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Les récepteurs solubles de l'interleukine-2 au cours de la radiothérapie des cancers du sein
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We assessed the relationships between soluble interleukin-2 receptor (R-IL2s) circulating concentrations and the clinicobiological characteristics of 80 breast cancer patients treated by radiotherapy. We did not evidenced significant relationships between R-IL2s concentrations before radiotherapy and patient's or tumours characteristics. However, R-IL2s concentrations were found to be positively correlated to lymphocyte levels and cumulated radiations dose during radiotherapy. Radiotherapy-induced lymphocyte lysis increases R-IL2s concentration among patients having a normal lymphocyte level (>Â 1,4 G/L) (PÂ =Â 0.01). In recurrent breast cancer, median R-IL2s concentrations were significantly elevated when compared to recurrence-free patients: median 41,5 pM/l (range: 15,6-146.0 pM/l) for metastatic patients and 53,1 pM/l (range: 36.0-70,2 pM/l) in case of contralateral cancer versus 36,6 pM/l (range: 1-169,6 pM/l) without any event (PÂ =Â 0.0002). In our series of breast cancers, mainly composed of stage I and II tumours, we found no prognostic value of initial R-IL2s concentration with regard to first recurrence.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immuno-analyse & Biologie Spécialisée - Volume 20, Issue 5, October 2005, Pages 308-314
Journal: Immuno-analyse & Biologie Spécialisée - Volume 20, Issue 5, October 2005, Pages 308-314
نویسندگان
H. Galinat, A.-M. Hersant, P. Rambert, J.-L. Floiras, C. Cohen-Solal, B. De La Lande, M.-F. Pichon,