کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9913650 1550642 2005 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Phox2b function in the enteric nervous system is conserved in zebrafish and is sox10-dependent
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Phox2b function in the enteric nervous system is conserved in zebrafish and is sox10-dependent
چکیده انگلیسی
Zebrafish lacking functional sox10 have defects in non-ectomesenchymal neural crest derivatives including the enteric nervous system (ENS) and as such provide an animal model for human Waardenburg Syndrome IV. Here, we characterize zebrafish phox2b as a functionally conserved marker of the developing ENS. We show that morpholino-mediated knockdown of Phox2b generates fish modeling Hirschsprung disease. Using markers, including phox2b, we investigate the ontogeny of the sox10 ENS phenotype. As previously shown for melanophore development, ENS progenitor fate specification fails in these mutant fish. However, in addition, we trace back the sox10 mutant ENS defect to an even earlier time point, finding that most neural crest cells fail to migrate ventrally to the gut primordium.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mechanisms of Development - Volume 122, Issue 5, May 2005, Pages 659-669
نویسندگان
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