کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9914969 1551021 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Thyroid dysfunction in megalin deficient mice
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Thyroid dysfunction in megalin deficient mice
چکیده انگلیسی
Megalin mediates transcytosis of thyroglobulin (Tg), the thyroid hormone precursor, resulting in its passage into the bloodstream. The process involves especially hormone-poor Tg, which may favour hormone secretion by preventing competition with hormone-rich Tg for proteolytic degradation. To gain more insight into the role of megalin, here we studied thyroid function and histology in megalin deficient mice compared with WT mice. As expected from the knowledge that megalin mediates Tg transcytosis, serum Tg levels were significantly reduced in homozygous (megalin−/−) mice, which, more importantly, were found to be hypothyroid, as demonstrated by significantly reduced serum free thyroxine and significantly increased serum thyroid stimulating hormone (TSH) levels. In heterozygous (megalin+/−) mice, in which megalin expression was normal, thyroid function was unaffected. Although the serological phenotype in megalin−/− mice was not associated with histological alterations or goiter, our results support a major role of megalin in thyroid hormone secretion.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 236, Issues 1–2, 31 May 2005, Pages 43-47
نویسندگان
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