کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9916169 | 1551159 | 2005 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Activation of p38 and p42/44 MAP kinase in neuropathic pain: Involvement of VPAC2 and NK2 receptors and mediation by spinal glia
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کلمات کلیدی
PPTVIPCCIPACAPchronic constriction injury - آسیب زدگی مزمنtumor necrosis factor-α - تومور نکروز عامل αTNF-α - فاکتور نکروز توموری آلفاmitogen-activated protein kinase - پروتئین کیناز فعال با mitogenPropentofylline - پروپنتوفیلینVasoactive intestinal polypeptide - پلیپپتید روده روغنیpituitary adenylate cyclase-activating peptide - پپتید فعال فعال آدنیلات سیکلاس هیپوفیزMAP kinase - کیناز MAP
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Activation of intracellular signaling pathways involving p38 and p42/44 MAP kinases may contribute importantly to synaptic plasticity underlying spinal neuronal sensitization. Inhibitors of p38 or p42/44 pathways moderately attenuated responses of dorsal horn neurons evoked by mustard oil but not brush and alleviated the behavioral reflex sensitization seen following nerve injury. Activation of p38 and p42/44 MAP kinases in spinal cord ipsilateral to constriction injury was reduced by antagonists of NMDA, VPAC2 and NK2 (but not related) receptors, the glial inhibitor propentofylline and inhibitors of TNF-α. A VPAC2 receptor agonist enhanced p38 phosphorylation and caused behavioral reflex sensitization in naïve animals that could be blocked by co-administration of p38 inhibitor. Conversely, an NK2 receptor agonist activated p42/44 and caused behavioral sensitization that could be prevented by co-administration of p42/44 inhibitor. Thus, spinal p38 and p42/44 MAP kinases are activated in neuropathic pain states by mechanisms involving VPAC2, NK2, NMDA receptors and glial cytokine production.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Neuroscience - Volume 30, Issue 4, December 2005, Pages 523-537
Journal: Molecular and Cellular Neuroscience - Volume 30, Issue 4, December 2005, Pages 523-537
نویسندگان
E.M. Garry, A. Delaney, G. Blackburn-Munro, T. Dickinson, A. Moss, I. Nakalembe, D.C. Robertson, R. Rosie, P. Robberecht, R. Mitchell, S.M. Fleetwood-Walker,