Effects of RM-β-CD on sublingual bioavailability of Δ9-tetrahydrocannabinol in rabbits

These results demonstrate that RM-β-CD increases both the aqueous solubility and dissolution rate of these cannabinoids, making the development of novel sublingual formulation possible. These results also suggest that the sublingual administration of a THC/RM-β-CD complex substantially increases the bioavailability of THC in rabbits.