کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9917743 | 1556311 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Selenocarbamates are effective superoxide anion scavengers in vitro
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Selenocarbamates are effective superoxide anion scavengers in vitro Selenocarbamates are effective superoxide anion scavengers in vitro](/preview/png/9917743.png)
چکیده انگلیسی
We investigated the superoxide anion-scavenging effects of six selenocarbamates and four thiocarbamates, using a highly sensitive quantitative chemiluminescence method. At 333Â nM, six selenocarbamates and four thiocarbamates scavenged in the range of 2.9-68.7% of O2â. Se-methyl N-phenylselenocarbamate and Se-methyl N-(4-methylphenyl)selenocarbamate exhibited the strongest superoxide anion-scavenging activity among the Se-selenocarbamates. In contrast, the corresponding S-thiocarbamates had moderate inhibitory effect. The 50% inhibitory concentrations (IC50) of Se-methyl-N-phenylselenocarbamate and Se-methyl-N-(4-methylphenyl)selenocarbamate were determined to be 140Â nM and 162Â nM, respectively. Thus, these compounds acted in vitro as effective and potentially useful O2â scavengers.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutical Sciences - Volume 24, Issue 4, March 2005, Pages 291-295
Journal: European Journal of Pharmaceutical Sciences - Volume 24, Issue 4, March 2005, Pages 291-295
نویسندگان
Hitoe Takahashi, Atsuyoshi Nishina, Ryo-hei Fukumoto, Hirokazu Kimura, Mamoru Koketsu, Hideharu Ishihara,