کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9917749 | 1556311 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Correlation between the release characteristics of theophylline and the free volume of polyvinylpyrrolidone
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Correlation between the release characteristics of theophylline and the free volume of polyvinylpyrrolidone Correlation between the release characteristics of theophylline and the free volume of polyvinylpyrrolidone](/preview/png/9917749.png)
چکیده انگلیسی
The purpose of this work was to study the drug-release properties of an amorphous polymer, polyvinylpyrrolidone applied conventionally as a binder in tablets. In order to gain data on the wearing properties of tablets, they were stored for a 30 days period under different humidity conditions before the drug-release measurements. The active material chosen for the release study was theophylline. An exponential relationship was found, with good correlation, between the relative humidity of the storage medium and the mean dissolution time of theophylline from polyvinylpyrrolidone tablets and the size of free volume holes. Positron annihilation lifetime spectroscopy (PALS) measurements, performed parallel with the theophylline release study, showed that the main reason for this correlation is the rearrangement of the pore structure of PVP. The results suggest that the water-induced glassy to rubbery transition of the polymer plays a significant role in the drug-release characteristics.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutical Sciences - Volume 24, Issue 4, March 2005, Pages 351-354
Journal: European Journal of Pharmaceutical Sciences - Volume 24, Issue 4, March 2005, Pages 351-354
نویسندگان
Romána Zelkó, Károly Süvegh,