کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9920920 | 1559194 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Resveratrol protects against cold ischemia-warm reoxygenation-induced damages to mitochondria and cells in rat liver
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Resveratrol protects against cold ischemia-warm reoxygenation-induced damages to mitochondria and cells in rat liver Resveratrol protects against cold ischemia-warm reoxygenation-induced damages to mitochondria and cells in rat liver](/preview/png/9920920.png)
چکیده انگلیسی
Resveratrol inhibits lipid peroxidation and protects mitochondrial functions. It improves respiratory chain activity and prevents opening of the permeability transition pore, allowing better recovery of ATP energetic charge. Resveratrol also limits the activation of the cellular markers of necrosis and apoptosis. These protective effects could be related to the antioxidant properties of the drug but also to its membrane-stabilizing activity. Indeed, further experiments demonstrate that resveratrol is able to prevent the release of cytochrome c caused by oxygen deprivation in isolated liver mitochondria. These data demonstrate that resveratrol ameliorates the liver injury induced by CPWR and appears as a promising drug to improve the primary function of the grafted liver after transplantation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 528, Issues 1â3, 28 December 2005, Pages 162-168
Journal: European Journal of Pharmacology - Volume 528, Issues 1â3, 28 December 2005, Pages 162-168
نویسندگان
Catherine Plin, Jean-Paul Tillement, Alain Berdeaux, Didier Morin,