کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9921062 | 1559200 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Goniothalamin induces cell cycle-specific apoptosis by modulating the redox status in MDA-MB-231 cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Goniothalamin induces cell cycle-specific apoptosis by modulating the redox status in MDA-MB-231 cells Goniothalamin induces cell cycle-specific apoptosis by modulating the redox status in MDA-MB-231 cells](/preview/png/9921062.png)
چکیده انگلیسی
Goniothalamin, a natural occurring styryl-lactone, is a novel compound with putative anticancer activities. In the present study, the mechanism of action of goniothalamin was further investigated in human breast cancer MDA-MB-231 cells. Goniothalamin treatment of cells significantly induced cell cycle arrest at G2/M phase and apoptosis. By means of cell cycle synchronization, the G2/M phase cells proved to be the most sensitive fraction to goniothalamin-induced apoptosis. Cells treated with goniothalamin revealed an increase in intracellular reactive oxygen species and a decrease in intracellular free thiol contents. The disruption of intracellular redox balance caused by goniothalamin was associated an enhancement of cdc25C degradation. Furthermore, the antioxidant N-acetylcysteine and the glutathione synthesis inhibitor dl-buthionine-(S, R)-sulfoximine, inhibited and enhanced, respectively, the effects of goniothalamin on cell cycle arrest and apoptosis. Taken together, our result demonstrates for the first time that goniothalamin disrupts intracellular redox balance and induces cdc25C degradation, which in turn causes cell cycle arrest and cell death maximally at G2/M phase in MDA-MB-231 cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 522, Issues 1â3, 17 October 2005, Pages 20-29
Journal: European Journal of Pharmacology - Volume 522, Issues 1â3, 17 October 2005, Pages 20-29
نویسندگان
Wen-Ying Chen, Chin-Chung Wu, Yu-Hsuan Lan, Fang-Rong Chang, Che-Ming Teng, Yang-Chang Wu,