کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9921167 | 1559204 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Tungstate stimulates insulin release and inhibits somatostatin output in the perfused rat pancreas
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Tungstate stimulates insulin release and inhibits somatostatin output in the perfused rat pancreas Tungstate stimulates insulin release and inhibits somatostatin output in the perfused rat pancreas](/preview/png/9921167.png)
چکیده انگلیسی
In the rat pancreas, infusion of sodium-tungstate stimulates basal insulin release in a dose-dependent manner. We have studied tungstate's effects on the insulin secretion elicited by various B-cell secretagogues. Somatostatin output was also measured. The study was performed in the perfused pancreas isolated from normal or somatostatin-depleted pancreases as induced by cysteamine pre-treatment. In control rats, tungstate co-infusion (5 mM) potentiated the insulin secretory responses to glucose (2.7-fold; PÂ <Â 0.01), arginine (2-fold; PÂ <Â 0.01), exendin-4 (3-fold; PÂ <Â 0.01), glucagon (4-fold; PÂ <Â 0.05), and tolbutamide (2-fold; PÂ <Â 0.01). It also inhibited the somatostatin secretory responses to glucose (90%; PÂ <Â 0.01), arginine (95%; PÂ <Â 0.01), glucagon (80%; PÂ <Â 0.025), exendin-4 (80%; PÂ <Â 0.05) and tolbutamide (85%; PÂ <Â 0.01). In somatostatin-depleted pancreases, the stimulatory effect of tungstate on basal insulin secretion and its potentiation of arginine-induced insulin output were comparable to those found in control rats. Our observations suggest an amplifying effect of tungstate on a common step in the insulin stimulus/secretion coupling process, and would rule out a paracrine effect mediated by the inhibition of somatostatin secretion induced by this compound.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 519, Issues 1â2, 5 September 2005, Pages 127-134
Journal: European Journal of Pharmacology - Volume 519, Issues 1â2, 5 September 2005, Pages 127-134
نویسندگان
Ramona A. Silvestre, Eva M. Egido, Raquel Hernández, José Marco,