کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9921240 | 1559208 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Streptozotocin-induced diabetes differentially modifies haloperidol- and γ-hydroxybutyric acid (GHB)-induced catalepsy
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
To examine whether dopamine-mediated behavioral effects are altered in diabetes, this study compared the cataleptic effects of the dopamine receptor antagonist haloperidol (0.032-0.56 mg/kg) and γ-hydroxybutyric acid (GHB; 56-1000 mg/kg) in control and streptozotocin (STZ)-treated rats. Haloperidol and GHB produced catalepsy in control and diabetic rats; haloperidol was less potent in diabetic rats (D50 = 0.44 mg/kg) than in controls (D50 = 0.19 mg/kg), while GHB was more potent in diabetic rats (D50 = 392 mg/kg) than in controls (D50 = 550 mg/kg). In diabetic rats, the non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist dizocilpine (0.32 mg/kg) further attenuated haloperidol-induced catalepsy (D50 = 1.2 mg/kg) and further enhanced GHB-induced catalepsy (D50 = 248 mg/kg). That haloperidol is less potent to produce catalepsy in diabetic rats is consistent with reports of altered dopamine receptor binding in diabetes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 517, Issues 1â2, 4 July 2005, Pages 64-67
Journal: European Journal of Pharmacology - Volume 517, Issues 1â2, 4 July 2005, Pages 64-67
نویسندگان
Rajkumar J. Sevak, Wouter Koek, Charles P. France,