کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9921378 | 1559216 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Histidine and carnosine delay diabetic deterioration in mice and protect human low density lipoprotein against oxidation and glycation
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Histidine and carnosine delay diabetic deterioration in mice and protect human low density lipoprotein against oxidation and glycation Histidine and carnosine delay diabetic deterioration in mice and protect human low density lipoprotein against oxidation and glycation](/preview/png/9921378.png)
چکیده انگلیسی
In vivo effects of histidine and carnosine against diabetic deterioration in diabetic Balb/cA mice were studied. Histidine and carnosine at 0.5, 1 g/l were added into drinking water. After 4 weeks intake of these agents, the content of histidine and carnosine in plasma, heart and liver significantly elevated (P<0.05). The intake of these agents significantly decreased plasma glucose and fibronectin levels (P<0.05); however, only 1 g/l histidine and carnosine treatments significantly increased insulin level (P<0.05) in diabetic mice. Triglyceride level in heart and liver was dose-dependently reduced by histidine or carnosine treatments (P<0.05); however, only 1 g/l histidine and carnosine treatments significantly reduced cholesterol level in heart and liver (P<0.05). The administration of histidine or carnosine significantly enhanced catalase activity and decreased lipid oxidation levels in kidney and liver (P<0.05); however, only 1 g/l histidine and carnosine treatments significantly increased glutathione peroxidase activity (P<0.05). The increased interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha in diabetic mice were significantly suppressed by the intake of histidine or carnosine (P<0.05). In human low density lipoprotein, histidine or carnosine showed dose-dependently suppressive effect in glucose-induced oxidation and glycation (P<0.05). These data suggest that histidine and carnosine are potential multiple-protective agents for diabetic complications prevention or therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 513, Issues 1â2, 18 April 2005, Pages 145-150
Journal: European Journal of Pharmacology - Volume 513, Issues 1â2, 18 April 2005, Pages 145-150
نویسندگان
Yuan-ti Lee, Cheng-chin Hsu, Meng-hsiao Lin, Keh-sen Liu, Mei-chin Yin,