کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9925404 | 1561946 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hemolysin chrysolysin⢠from Penicillium chrysogenum promotes inflammatory response
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
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چکیده انگلیسی
Some strains of Penicillium chrysogenum produce a proteinaceous hemolysin, chrysolysinâ¢, when incubated on sheep's blood agar at 37 °C but not at 23 °C. However, 92% (11/12) of the indoor air isolates produced hemolysis but only 43% (3/7) of the non-indoor air isolates did so. Chrysolysin is an aggregating protein composed of approximately 2 kDa monomers, contains one cysteine amino acid, and has an isoelectric point of 4.85. Treatment of murine macrophage cell line RAW 264.7 with purified chrysolysin caused statistically significant (T-test, p<0.05) increased production of macrophage inflammatory protein-2 (MIP-2) in a dose dependent manner after 6 h treatment. This suggests that chrysolysin might act to promote the host's inflammatory response after P. chrysogenum exposures.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Hygiene and Environmental Health - Volume 208, Issue 4, 20 July 2005, Pages 279-285
Journal: International Journal of Hygiene and Environmental Health - Volume 208, Issue 4, 20 July 2005, Pages 279-285
نویسندگان
Maura Donohue, Yongjoo Chung, Matthew L. Magnuson, Marsha Ward, Mary Jane Selgrade, Stephen Vesper,