کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9935985 1572432 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Analysis of Left Ventricular Systolic Function Using Midwall Mechanics in Patients >60 Years of Age With Hypertensive Heart Disease and Heart Failure
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Analysis of Left Ventricular Systolic Function Using Midwall Mechanics in Patients >60 Years of Age With Hypertensive Heart Disease and Heart Failure
چکیده انگلیسی
Normal ejection fraction (EFs) is often equated with normal systolic function. However, midwall mechanics reveal systolic dysfunction in hypertensive heart disease accompanied by hypertrophic remodeling. Midwall mechanics are unstudied in patients with acute diastolic heart failure (HF). This study analyzed left ventricular (LV) midwall stress-shortening relations in 61 patients aged >60 years with hypertensive heart disease, HF, and normal EF. Sixty-one hypertensive patients (mean age 78 ± 10 years) who presented with HF, each with an EF >50%, underwent echocardiography. Midwall mechanics were compared with those of 79 controls (mean age 75 ± 8 years) without structural heart disease. Relative wall thickness (0.63 ± 0.11 vs 0.46 ± 0.10 mm) and LV mass (237 ± 67 vs 177 ± 57 g) were significantly greater in patients with HF compared with controls. Mean EFs were similar in patients with HF and controls (64 ± 9% vs 67 ± 9%). Although mean endocardial fractional shortening (35 ± 7% vs 37 ± 7%) was not significantly different, midwall shortening in patients with HF was significantly less compared with controls (16 ± 2% vs 19 ± 3%, p <0.05). Eighteen of the 61 patients with HF (30%) had midwall shortening that was <95% confidence intervals of the normal midwall stress-shortening relations. By this criterion, these patients had systolic dysfunction despite normal EF; they had smaller LV chambers (in dimension and volume), greater relative wall thickness, and smaller stroke volumes. In conclusion, almost 1/3 of patients hospitalized with diastolic HF had systolic dysfunction, characterized by abnormal midwall stress-shortening relations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The American Journal of Cardiology - Volume 96, Issue 9, 1 November 2005, Pages 1299-1303
نویسندگان
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