Urinary 8-Hydroxy-2′-Deoxyguanosine levels increase after reperfusion in acute myocardial infarction and may predict subsequent cardiac events

We assessed serial changes in oxidative stress in patients with acute myocardial infarction by measuring urinary 8-hydroxy-2′-deoxyguanosine excretion. The urinary 8-hydroxy-2′-deoxyguanosine creatinine levels peaked at 4 hours after reperfusion therapy and the levels were higher in the cardiac event group than in the noncardiac event group before and after reperfusion.