Quantitative Trait Loci Mapping for Intracellular Calcium in Spontaneously Hypertensive Rats

A significant QTL for [Ca2+]i was mapped near Serca2 on chromosome 12, and suggestive QTL were identified near D3Mit13 and DXMgh1 in a genome scan. Genetic abnormalites in platelet [Ca2+]i may contribute to cardiovascular disease via platetet hyperactivity, independent of blood pressure elevation.