کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9942523 | 1573259 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Acquired Bartter-Like Syndrome Associated with Gentamicin Administration
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
Although acute nonoliguric renal failure is a well-known nephrotoxic effect of aminoglycoside antibiotics, less recognized is acquired Bartter-like syndrome. Herein, we describe four female patients who presented with marked paresthesia, muscle weakness, and tetany following gentamicin therapy with total dose ranging from 1.2Â g to 2.6Â g. All were normotensive. Biochemical abnormalities included hypokalemia (K+ 1.8-2.3Â mmol/L), metabolic alkalosis (HCO3â 31.9-34.2Â mmol/L), hypomagnesemia (Mg2Â + 0.9-1.2Â mg/dL), hypermagnesiuria (fractional excretion of Mg 3-6%), hypocalcemia (free Ca2Â + 2.0-4.1Â mg/dL), and hypercalciuria (molar ratio of Ca2Â +/creatinine 0.23-0.53), all consistent with Bartter-like syndrome. Serum immuno-reactive parathyroid hormone concentration was low despite the hypocalcemia. The Bartter-like syndrome lasted for 2 to 6 weeks after cessation of gentamicin, coupled with supplementation of K+, Ca2Â +, and Mg2Â +. These biochemical abnormalities resembled those seen in patients with gain-of-function mutations in the calcium-sensing receptor. We hypothesize that gentamicin, a polyvalent cationic molecule, induces the action of calcium-sensing receptor on the thick ascending loop of Henle and distal convoluted tubule to cause renal wasting of Na+, K+, Cr, Ca2Â +, and Mg2Â +.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The American Journal of the Medical Sciences - Volume 329, Issue 3, March 2005, Pages 144-149
Journal: The American Journal of the Medical Sciences - Volume 329, Issue 3, March 2005, Pages 144-149
نویسندگان
Chu-Lin MD, Tom MD, Shih-Hua MD, Yeong-Hwang MD,