کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9952823 1469057 2018 27 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A three-dimensional micromechanical model of brain white matter with histology-informed probabilistic distribution of axonal fibers
ترجمه فارسی عنوان
یک مدل میکرومکانیکی سه بعدی ماده سفید مغز با توزیع احتمال احتمالی بافت شناسی ایزوالکتریک
کلمات کلیدی
خصوصیات هیپرآلازتی، تکنیک عنصر جاسازی شده تغییر شکل بزرگ، بهینه سازی چند هدفه،
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
چکیده انگلیسی
This paper presents a three-dimensional micromechanical model of brain white matter tissue as a transversely isotropic soft composite described by the generalized Ogden hyperelastic model. The embedded element technique, with corrected stiffness redundancy in large deformations, was used for the embedment of a histology-informed probabilistic distribution of the axonal fibers in the extracellular matrix. The model was linked to a multi-objective, multi-parametric optimization algorithm, using the response surface methodology, for characterization of material properties of the axonal fibers and extracellular matrix in an inverse finite element analysis. The optimum hyperelastic characteristics of the tissue constituents, obtained based on the axonal and transverse direction test results of the corona radiata tissue samples, indicated that the axonal fibers were almost thirteen times stiffer than the extracellular matrix under large deformations. Simulation of the same tissue under a different loading condition, as well as that of another white matter tissue, i.e., the corpus callosum, in the axonal and transverse directions, using the optimized hyperelastic characteristics revealed tissue responses very close to those of the experiments. The results of the model at the sub-tissue level indicated that the stress concentrations were considerably large around the small axons, which might contribute into the brain injury.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Mechanical Behavior of Biomedical Materials - Volume 88, December 2018, Pages 288-295
نویسندگان
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