کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9953991 | 1534286 | 2018 | 49 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The effect of fasting or calorie restriction on autophagy induction: A review of the literature
ترجمه فارسی عنوان
تأثیر محدودیت ناشتا یا کالری در القاء اتوفایگی: بررسی ادبیات
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
AMPKSirt1mTORATGLC3ULK1LAMP2AMP-activated protein kinase - AMP-پروتئین کیناز فعال شده استAutophagy - اتوفاژیFasting - روزه داریcalorie restriction - محدودیت کالریmammalian target of rapamycin - هدف پستانداران رپامایسینlysosomal-associated membrane protein 2 - پروتئین غشای مرتبط با لیزوزوم 2microtubule-associated protein 1 light chain 3 - پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3autophagy-related genes - ژن های مربوط به autophagy
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Autophagy is a lysosomal degradation process and protective housekeeping mechanism to eliminate damaged organelles, long-lived misfolded proteins and invading pathogens. Autophagy functions to recycle building blocks and energy for cellular renovation and homeostasis, allowing cells to adapt to stress. Modulation of autophagy is a potential therapeutic target for a diverse range of diseases, including metabolic conditions, neurodegenerative diseases, cancers and infectious diseases. Traditionally, food deprivation and calorie restriction (CR) have been considered to slow aging and increase longevity. Since autophagy inhibition attenuates the anti-aging effects of CR, it has been proposed that autophagy plays a substantive role in CR-mediated longevity. Among several stress stimuli inducers of autophagy, fasting and CR are the most potent non-genetic autophagy stimulators, and lack the undesirable side effects associated with alternative interventions. Despite the importance of autophagy, the evidence connecting fasting or CR with autophagy promotion has not previously been reviewed. Therefore, our objective was to weigh the evidence relating the effect of CR or fasting on autophagy promotion. We conclude that both fasting and CR have a role in the upregulation of autophagy, the evidence overwhelmingly suggesting that autophagy is induced in a wide variety of tissues and organs in response to food deprivation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ageing Research Reviews - Volume 47, November 2018, Pages 183-197
Journal: Ageing Research Reviews - Volume 47, November 2018, Pages 183-197
نویسندگان
Mohammad Bagherniya, Alexandra E. Butler, George E. Barreto, Amirhossein Sahebkar,