Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; NAFLD; nonalcoholic fatty liver disease; NASH; nonalcoholic steatohepatitis; FC; free cholesterol; VLDL; very low density lipoprotein; LDL; low density lipoprotein; mTOR; mechanistic target of rapamycin signaling; AMPK; AMP-activated protein kinase; TG; t
مقالات ISI پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3 (ترجمه نشده)
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Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; MAP1LC3; microtubule-associated protein 1 light chain 3; LAMP1; lysosomes associated membrane protein 1; ROS; reactive oxygen species; EGCG; epigallocatechin gallate; CCCP; carbonyl cyanide 3-chlorophenylhydrazone; VDAC1; voltage-dependent anion-selective
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; Atg; autophagy-related genes; LC3; microtubule-associated protein 1 light chain 3; Sirt1; silent mating type information regulation 1; LAMP2; lysosomal-associated membrane protein 2; ULK1; Unc-51-like Kinase-1; AMPK; AMP-activated protein kinase; mTOR; ma
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; Autophagy; Melanosome transfer; MyosinVa; Tyrosinase; LC3; Microtubule-associated protein 1 light chain 3; siMyosinVa; MyosinVa-small interfering RNA;
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; Atg; autophagy-related protein; LC3; microtubule-associated protein 1 light chain 3; SNARE; N-ethylmaleimide-sensitive factor attachment protein receptor; Stx17; syntaxin 17; SQSTM1; sequestosome 1; TcPV; T. cruzi parasitophorous vacuole; VAMP8; vesicle-a
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; AG; aminoguanidine; CAA; complete amino acids; DMEM; Dulbecco's Modified Eagle's Medium; EBSS; Earle's Balanced Salt Solution; LC3; microtubule-associated protein 1 light chain 3; LC3-IIs; cytosolic (soluble) form of LC3-II; l-NMMA; NG-monomethyl-l-
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; Akt; protein kinase B; AL; ad labitum; BDNF; brain-derived neurotrophic factor; CR; caloric restriction; LC3; microtubule-associated protein 1 light chain 3; mTOR; mammalian target of rapamycin; MWM; Morris water maze; OFT; open field test; PI3K; phosphat
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; 31P-NMR; 31P nuclear magnetic resonance; AIF; apoptosis-inducing factor; AngII; angiotensin II; Atg protein; autophagy-related protein; Bcl-2; B-cell leukemia-2; COPD; chronic obstructive pulmonary disease; COX; cytochrome c oxidase; CSA; cross-sectional
FoxO1-mediated autophagy plays an important role in the neuroprotective effects of hydrogen in a rat model of vascular dementia
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; Atg7; autophagy associated gene 7; Bax; Bcl-2 associated X protein; Bak; Bcl-2 homologous antagonist/killer; Bcl-2; B-cell lymphoma-2; Beclin 1; Bcl-2 interacting protein 1; CCH; chronic cerebral hypoperfusion; Cleaved caspase-3; Cleaved cysteinyl asparta
Mitophagy is activated in brain damage induced by cerebral ischemia and reperfusion via the PINK1/Parkin/p62 signalling pathway
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; PINK1; PTEN-induced kinase 1; i.p.; intraperitoneal; CCA; common carotid artery; ECA; external carotid artery; ICA; internal carotid artery; MCAO; middle cerebral artery occlusion; H&E; haematoxylin and eosin; LC3; Microtubule-associated protein 1 light c
ATG4B inhibitor FMK-9a induces autophagy independent on its enzyme inhibition
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; Atg4B; Autophagy; Delipidation; FMK-9a; FRET assay; Atg4B; autophagy-related 4B; Baf; bafilomycin A1; CM; complete medium; CQ; chloroquine; EBSS; Earle's Balanced Salt Solution; FMK; fluoromethylketone; FRET; fluorescence resonance energy transfer; GABARA
Caffeic acid and resveratrol ameliorate cellular damage in cell and Drosophila models of spinocerebellar ataxia type 3 through upregulation of Nrf2 pathway
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; ARE; antioxidant response element; Bcl-2; B-cell lymphoma 2; CA; caffeic acid; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; GCLC; glutamate-cysteine ligase catalytic subunit; GCLM; gl
Aqueous extracts of Paeonia suffruticosa modulates mitochondrial proteostasis by reactive oxygen species-induced endoplasmic reticulum stress in pancreatic cancer cells
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; Chinese herbal medicine; Paeonia suffruticosa; Pancreatic cancer; Proteostasis; Autophagy; Apoptosis; 5GG; penta-O-galloyl-β-D-glucose hydrate; CHM; Chinese herbal medicine; DCFDA; 2â²-7â²-dichlorofluorescin diacetate; EGFR; epidermal growth factor rec
Monitoring autophagic flux using p62/SQSTM1 based luciferase reporters in glioma cells
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; 3-MA; 3-methyladenine; CQ; Chloroquine; Rapa; Rapamycin; EBSS; Dulbecco's Phosphate-Buffered Saline; ATG5; Autophagy-related 5; MAP1LC3/LC3; Microtubule-associated protein 1 light chain 3; mTOR; Mammalian (or mechanistic) Target of Rapamycin; SQSTM1; sequ
Ginsenoside Rh4 induces apoptosis and autophagic cell death through activation of the ROS/JNK/p53 pathway in colorectal cancer cells
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; ROS; reactive oxygen species; MAPK; mitogen-activated protein kinase; JNK; c-Jun N-terminal Kinase; NAC; N-acetyl-cysteine; LC3; microtubule-associated protein 1 light chain 3; 3-MA; 3-methyladenine; CCK-8; Cell Counting Kit-8; MMP; mitochondrial membrane
Acrolein induces NLRP3 inflammasome-mediated pyroptosis and suppresses migration via ROS-dependent autophagy in vascular endothelial cells
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; AS; atherosclerosis; CVD; cardiovascular diseases; ROS; reactive oxygen species; HUVECs; human umbilical vein endothelial cells; LPS; lipopolysaccharide; MTT; 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazo- lium bromide; DMSO; dimethyl sulfoxide; NAC;
Ultraviolet B radiation down-regulates ULK1 and ATG7 expression and impairs the autophagy response in human keratinocytes
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; UV; ultraviolet; ROS; reactive oxygen species; ATG; autophagy-related gene; MTOR; mechanistic target of rapamycin; ULK1; unc-51-like kinase 1; HEKs; human epidermal keratinocytes; LC3; microtubule-associated protein 1 light chain 3; E&P; E64d and pepstati
Autophagy in hemorrhagic stroke: Mechanisms and clinical implications
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; AIM2; absent in melanoma 2; AMPK; Adenosine 5â² monophosphate-activated protein kinase; ASC; apoptosis-associated speck-like protein containing a CARD; BBB; blood-brain barrier; BH3; Bcl-2 homology 3; BMVECs; brain microvascular endothelial cells; BNIP3;
Anti-osteoclastogenesis of Mineral Trioxide Aggregate through Inhibition of the Autophagic Pathway
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; Autophagy; microtubule-associated protein 1 light chain 3; mineral trioxide aggregate; osteoclastogenesis;
Resveratrol-induced autophagy is dependent on IP3Rs and on cytosolic Ca2Â +
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; Akt; protein kinase B; AMPK; AMP-activated protein kinase; BAPTA-AM; 1,2-bis(o-aminophenoxy)ethane-N,N,Nâ²,Nâ²-tetraacetic acid acetoxymethyl ester; DMEM; Dulbecco's modified Eagle's medium; EGTA; ethylene glycol tetraacetic acid; ER; endoplasmic reticu
Inhibition of stress induced premature senescence in presenilin-1 mutated cells with water soluble Coenzyme Q10
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; Aβ; amyloid-beta peptide; AD; Alzheimer's disease; APP; amyloid precursor protein; CoQ10; Coenzyme Q10; DCF; 2â²,7â²-dichlorofluorescein; DIC; differential interference contrast; H2DCFDA; 2â²-7â²-dichlorofluorescin diacetate; HBSS; Hank's Balanced Sa
Pharbitis Nil (PN) induces apoptosis and autophagy in lung cancer cells and autophagy inhibition enhances PN-induced apoptosis
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; PN; Pharbitis Nil; ERK1/2; Extracellular signal-regulated kinases 1 and 2; STAT3; Signal transducer and activator of transcription 3, RT-PCR, Reverse transcriptase -polymerase chain reaction; siRNA; Small interfering RNA; PARP; poly ADP-ribose polymerase;
DNA damage response and autophagy in the degeneration of retinal pigment epithelial cells-Implications for age-related macular degeneration (AMD)
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; 9-1-1 complex; complex of Rad9 Rad1 and Hus1 proteins; A2E; N-retinylidene-N-retinylethanol-amine; AtRal; all-trans retinal; AMD; age-related macular degeneration; AMPK; AMP-activated protein kinase; Atg; autophagy-related gene; ATM; ataxia-telangiectasia
Caveolin 1-related autophagy initiated by aldosterone-induced oxidation promotes liver sinusoidal endothelial cells defenestration
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; 3MA; 3-methyladenine; AMPK; AMP-activated protein kinase; ATP; adenosine triphosphate; ATP1B2; ATPase Na+/K+ transporting subunit beta 2; BDL; bile duct ligation; Cav1; Caveolin 1; CD31; platelet endothelial cell adhesion molecule-1, PECAM-1; cGMP; cyclic
Dehydropachymic acid decreases bafilomycin A1 induced β-Amyloid accumulation in PC12 cells
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; AD; Alzheimer's disease; ALP; autophagy-lysosome pathway; APP; amyloid precursor protein; ATG; autophagy-related gene; AVs; autophagic vacuoles; Aβ; β-amyloid peptide; DPA; dehydropachymic acid; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GSK-3; Gl
Dihydroceramide desaturase inhibitors induce autophagy via dihydroceramide-dependent and independent mechanisms
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; 3MA; 3-methyladenine; C22:0-dhCer; docosanoylsphinganine; C24:0-dhCer; N-tetracosanoylsphinganine; C24:1-dhCer; N-tetracosenoylsphinganine; CCX; celecoxib; Cer; ceramide; CerS; ceramide synthase; d2C8dhCer; N-octanoyl-d-erythro-[4,4-2H2]sphinganine; Des1;
Research articleInsulin on activation of autophagy with integrins and syndecans against MPP+-induced α-synuclein neurotoxicity
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; α-Syn, SNCA; α-synuclein; Cox-2; cyclooxygenase-2; ILK; integrin-linked kinase; ITGAV; integrin αV; ITGB3; integrin β3; LDH; lactate dehydrogenase; MAP1LC3; microtubule-associated protein 1 light chain 3; MPP+; 1-Methyl-4-phenyl pyridinium; SDC1; synd
Biphasic effects of l-ascorbate on the tumoricidal activity of non-thermal plasma against malignant mesothelioma cells
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; l-ascorbate; Non-thermal plasma (NTP); Reactive oxygen species (ROS); Autophagy; Mesothelioma; ANOVA; analysis of variance; DAPI; 4â²,6-diamidino-2-phenylindole; DFO; deferoxamine mesylate salt; EM; epithelioid mesothelioma; HBSS; Hanks' balanced salt
Herp depletion inhibits zearalenone-induced cell death in RAW 264.7 macrophages
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; Atg; autophagy-related proteins; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; ER; endoplasmic reticulum; ERAD; ER-associated protein degradation; FBS; fetal bovine serum; Fisher LSD; Fisher's least significant different test; GS; gl
Exaggerated arsenic nephrotoxicity in female mice through estrogen-dependent impairments in the autophagic flux
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; NaAsO2; sodium arsenite; PAS; periodic acid Schiff; SOCS3; suppressor of cytokine signaling-3; Ab; antibody; NGAL; neutrophil gelatinase-associated lipocalin; BUN; blood urea nitrogen; CRE; creatinine; LC3; microtubule-associated protein 1 light chain 3;
Differential effects of GLP-1 receptor agonist on foam cell formation in monocytes between non-obese and obese subjects
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; AGEs; advanced glycation end products; DPP-4; dipeptidyl peptidase-4; Ex-4; exendin-4; GLP-1; glucagon-like peptide-1; GLP-1R; GLP-1 receptor; LC3; microtubule-associated protein 1 light chain 3; MÏ; macrophages; NF-κB; muclear factor-κB; Ox-LDL; oxidi
ROS-JNK1/2-dependent activation of autophagy is required for the induction of anti-inflammatory effect of dihydroartemisinin in liver fibrosis
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; ALT; alanine aminotransferase; AST; aspartate aminotransferase; ALP; alkaline phosphatase; Atg; autophagy-related gene; α-SMA; alpha smooth muscle actin; Cat; catalase; DHA; dihydroartemisinin; ERK1/2; extracellular regulated kinase1/2; GSH; glutathione;
Involvement of autophagy upregulation in 3,4-methylenedioxymethamphetamine ('ecstasy')-induced serotonergic neurotoxicity
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; MDMA; 3,4-methylenedioxymethamphetamine; LC3; microtubule-associated protein 1 light chain 3; SERT; serotonin transporter; TPH; tryptophan hydroxylase; SSRIs; selective serotonin reuptake inhibitors; 5-HT; 5-hydroxytryptamine (serotonin); 3-MA; 3-methylad
SIRT6 suppresses isoproterenol-induced cardiac hypertrophy through activation of autophagy
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; Atgs; autophagy-related genes; ANF; atrial natriuretic factor; BNP; brain natriuretic polypeptide; FoxO3; forkhead box O3; LC3; microtubule-associated protein 1 light chain 3; IF; immunofluorescence; NRCMs; neonatal rat cardiomyocytes; ISO; isoproterenol;
Telomerase reverse transcriptase induces basal and amino acid starvation-induced autophagy through mTORC1
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; Autophagy; Cell viability; Human telomerase reverse transcriptase (hTERT); Mammalian target of rapamycin complex 1 (mTORC1); Telomerase; AMPK; AMP-activated protein kinase; DMEM; Dulbecco's Modified Eagle's medium; EBSS; Earle's balanced salt solution; ER
Autophagy: A double-edged sword in intervertebral disk degeneration
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; IVD; intervertebral disk; NP; nucleus pulposus; AF; annulus fibrosus; CEPs; cartilaginous endplates; ECM; extracellular matrix; Col II; type II collagen; Col I; type I collagen; IDD; intervertebral disk degeneration; LBP; low back pain; miRNAs; microRNAs;
Autophagic down-regulation in motor neurons remarkably prolongs the survival of ALS mice
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; LC3; microtubule-associated protein 1 light chain 3; SOD1G93A; mutant human Cu/Zn superoxide dismutase; n-BP; n-butylidenephthalide; bid; two times a day; qd; one times a day;
Roseotoxin B Improves Allergic Contact Dermatitis through a Unique Anti-Inflammatory Mechanism Involving Excessive Activation of Autophagy in Activated T Lymphocytes
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; ACD; allergic contact dermatitis; CCCP; carbonyl cyanide m-chlorophenylhydrazone; ConA; concanavalin A; CQ; chloroquine; CsA; cyclosporine A; LC3; microtubule-associated protein 1 light chain 3; p27kip; cyclin-dependent kinase inhibitor p27; p-AKT; phosph
Tyrosine kinase inhibitor tyrphostin AG490 triggers both apoptosis and autophagy by reducing HSF1 and Mcl-1 in PEL cells
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; STAT3; Signal Transducer and Activator of Transcription 3 (gene); HSF1; Heat Shock Transcription Factor 1; HSP70; Heat Shock Protein 70; Mcl-1; Myeloid Cell Leukemia 1; LC3; Microtubule-Associated protein 1 light chain 3; p62; Sequestosome1/SQSTM1; PEL; P
Trans-Golgi protein p230/golgin-245 is involved in phagophore formation
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; AP2; adaptor-protein 2; EBSS; Earle's balanced salt solution; ER; endoplasmic reticulum; KD; knock-down; MACF1; microtubule actin crosslinking protein 1; LC3; microtubule-associated protein 1 light chain 3; PM; plasma membrane; TGN; trans-Golgi network;
Autophagic flux determination in vivo and ex vivo
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; ATP; adenosine triphosphate; BBB; blood brain barrier; BRB; blood retinal barrier; BGT; BSA/glycine/Triton X-100; BSA; bovine serum albumin; CNS; central nervous system; DABCO; 1,4-diazabicyclo[2.2.2]octane; DAPI; 4,6-diamidino-2-phenylindole dihydrochlor
Platycodin D triggers autophagy through activation of extracellular signal-regulated kinase in hepatocellular carcinoma HepG2 cells
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; PD; Platycodin D; CQ; chloroquine; DMSO; dimethylsulfoxide; MTT; 3-[4,5-Dimethyl-2-thiazolyl]-2,5-diphenyltetrazolium bromide; MDC; monodansylcadaverin; ERK; extracellular signal-regulated kinase; BAF; bafilomycin A1; LC3; microtubule-associated protein 1
How to reduce the accumulation of autophagic vacuoles in NPC1-deficient neurons: A comparison of two pharmacological strategies
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; Neurons; Niemann-Pick type C disease; Autophagy; Cyclodextrin; PI3K-inhibitor; CD; cyclodextrin; pCD; 2-hydroxy-propyl-β-cyclodextrin; LC3; microtubule-associated protein 1 light chain 3; LC3-I; phosphatidylethanolamine-deconjugated LC3; LC3-II; phosphat
Targeting pyruvate kinase M2 contributes to radiosensitivity of non-small cell lung cancer cells in vitro and in vivo
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; NSCLC; non-small cell lung cancer; PKM2; pyruvate kinase M2 isoform; pshRNA; the plasmid encoding a short hairpin RNA; IR; ionizing radiation; PEP; phosphoenolpyruvate; 3-MA; 3-methyladenine; Z-VAD; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl keto
Jinlida granule inhibits palmitic acid induced-intracellular lipid accumulation and enhances autophagy in NIT-1 pancreatic β cells through AMPK activation
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; JLDG; Jinlida granule; TCM; traditional Chinese medicine; ACC; acetyl-coA carboxylase; FAS; fatty acid synthase; CPT-1; carnitine acyl transferase 1; AMPK; AMP activated protein kinase; pAMPK; phospho-AMP activated protein kinase; SREBP-1c; sterol regulat
PINK1/Parkin-mediated mitophagy alleviates chlorpyrifos-induced apoptosis in SH-SY5Y cells
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; CCCP; carbonyl cyanide m-chlorophenyl hydrazone; CCK-8; cell counting kit-8; CPF; chlorpyrifos; DMSO; dimethyl sulfoxide; LC3; microtubule-associated protein 1 light chain 3; NDUFS3; nicotinamide adenine dinucleotide dehydrogenase Fe-S protein 3; ROS; rea
Research ReportAutophagy-related protein expression in the substantia nigra and eldepryl intervention in rat models of Parkinson׳s disease
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; PD; Parkinson׳s disease; LC3; microtubule-associated protein 1 light chain 3; PBS; phosphate buffered solution; Parkinson׳s disease; Substantia nigra; Autophagy; Beclin1; LC3; Eldepryl;
Psammaplin A induces Sirtuin 1-dependent autophagic cell death in doxorubicin-resistant MCF-7/adr human breast cancer cells and xenografts
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; AMPK; AMP-activated protein kinase; Atg; autophagy-related gene; BAX; Bcl-2-associated X protein; DNMT; DNA methyltransferase; Dox; doxorubicin; DRAM; damage-regulated autophagy modulator; HDAC; histone deacetylase; LC3; microtubule-associated protein 1 l
Decorin is an autophagy-inducible proteoglycan and is required for proper in vivo autophagy
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; Actb; β-actin; AMPK; adenosine monophosphate protein kinase; Bgn; biglycan; CDK; cyclin-dependent kinase; Dcn; decorin; EGFR; epidermal growth factor receptor; GFP; green fluorescent protein; IGF-IR; insulin-like growth factor receptor I; LC3; microtubul
Age-regulated function of autophagy in the mouse inner ear
Keywords: پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3; Ageing; ATG; Beclin 1; Cochlea; IGF1R; Otic development; Vestibule; ATG; autophagy-related gene; Cox2; cyclooxygenase 2; IGF-I; insulin-like growth factor I; LC3; microtubule-associated protein 1 light chain 3; PI3KC; phosphatidylinositol 3-kinase; PPLR;