کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6074504 | 1203487 | 2016 | 35 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Roseotoxin B Improves Allergic Contact Dermatitis through a Unique Anti-Inflammatory Mechanism Involving Excessive Activation of Autophagy in Activated T Lymphocytes
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کلمات کلیدی
ACDrps3p27KipPhosphorylated protein kinase Bphosphorylated signal transducer and activator of transcriptionConAPCLCCCPLC3Concanavalin Ap-Akt - P-AKTSTAT - آمارCSA - ایالات مؤتلفهٔ آمریکاACD, Allergic contact dermatitis - درماتیت تماسی آلرژیکCyclosporine A - سیکلوسپورینASignal transducer and activator of transcription - مبدل سیگنال و فعال کننده رونویسیretinoblastoma protein - پروتئین رتینوبلاستوماmicrotubule-associated protein 1 light chain 3 - پروتئین مرتبط با میکروتوبول 1 زنجیره سبک 3carbonyl cyanide m-chlorophenylhydrazone - کربنیل سیانید m-chlorophenylhydrazoneChloroquine - کلروکین
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
امراض پوستی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Roseotoxin B Improves Allergic Contact Dermatitis through a Unique Anti-Inflammatory Mechanism Involving Excessive Activation of Autophagy in Activated T Lymphocytes Roseotoxin B Improves Allergic Contact Dermatitis through a Unique Anti-Inflammatory Mechanism Involving Excessive Activation of Autophagy in Activated T Lymphocytes](/preview/png/6074504.png)
چکیده انگلیسی
An immunosuppressant agent with negligible or acceptable toxicity may provide a better therapeutic strategy for treatment of allergic contact dermatitis. We identified a natural cyclopeptide, roseotoxin B, that effectively suppressed cell proliferation and the production of proinflammatory cytokines in activated T cells but exhibited little naive T-cell toxicity at concentrations of 0.3-1 μmol/L. In addition, roseotoxin B inhibited the activation of AKT and signal transducer and activator of transcription-3, suppressed cell cycle-related signaling, caused G0/G1 phase arrest, reduced ribosomal protein-S3 (RPS3)-dependent NF-κB-mediated IL-2 production, and increased autophagy in activated T cells. Furthermore, picryl chloride-induced allergic contact dermatitis was significantly ameliorated by roseotoxin B in mice. The effects of roseotoxin B were inhibited in LC3-knockout mice, indicating that roseotoxin B acts in an autophagy-dependent manner in T-cell-mediated skin diseases. Overall, this study showed a mechanism for roseotoxin B-induced autophagic cell death and provided a unique perspective on autophagy-mediated down-regulation of NF-κB signaling in activated T cells. The unique anti-inflammatory mechanism of roseotoxin B against activated T lymphocytes in allergic contact dermatitis suggests that it could be a potential target for the treatment of immune-related skin diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Investigative Dermatology - Volume 136, Issue 8, August 2016, Pages 1636-1646
Journal: Journal of Investigative Dermatology - Volume 136, Issue 8, August 2016, Pages 1636-1646
نویسندگان
Xingqi Wang, Chunhui Hu, Xingxin Wu, Shiyu Wang, Aihua Zhang, Wei Chen, Yan Shen, Renxiang Tan, Xuefeng Wu, Yang Sun, Qiang Xu,