Keywords: پروتئین رتینوبلاستوما; α-CGRP; alpha-calcitonin gene related peptide; Ang; angiopoietin; AE2; anion exchanger 2; ADP; adenosine diphosphate; ADPKD; autosomal dominant polycystic kidney disease; ATP; adenosine triphosphate; ASBT; sodium-dependent bile acid transporter; AQP; aqu
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Keywords: پروتئین رتینوبلاستوما; Cell cycle; Posttranslational modifications; Reactive oxygen species; Retinoblastoma protein; Root apical meristem;
Keywords: پروتئین رتینوبلاستوما; AML; acute myeloid leukemia; CAK; CDK-activating kinase; CDK; cyclin-dependent kinases; CLL; chronic lymphocytic leukemia; CT; RNA polymerase II C-terminal domain; DLT; dose-limiting toxicities; DSIF; DRB-sensitivity inducing factor; ER; estrogen Receptor
Keywords: پروتئین رتینوبلاستوما; Retinal ganglion cells; Axon regeneration; Cancer genes; PTEN; Visual system repair mechanisms; AAV; Adeno-associated virus; CNS; Central Nervous System; CNTF; ciliary neurotrophic factor; DLK; dual leucine zipper kinase; DRG; dorsal root ganglion; EGFR;
Keywords: پروتئین رتینوبلاستوما; AIF; apoptosis inducing factor; Ang; angiopoietin; AP-1; activator protein-1; APEX; Assessment of Proteasome Inhibition for Extending Remissions; ATP; adenosine-5â²-triphosphate; BiPN; bortezomib-induced peripheral neuropathy; CiPN; chemotherapy-induced
Keywords: پروتئین رتینوبلاستوما; pRb; retinoblastoma protein; AI; apoptotic index; IAP; inhibitors of apoptosis proteins; Retinoblastoma; Apoptosis; bcl-X protein;
Keywords: پروتئین رتینوبلاستوما; 7-Hydroxystaurosporine (PubMed CID: 72271); Abemaciclib (PubMed CID: 46220502); Alvocidib (PubMed CID: 5287969); AT7519 (PubMed CID: 11338033); BMS-387032 (PubMed CID: 3025986); Dinaciclib (PubMed CID: 46926350); Palbociclib (PubMed CID: 5330286); Ribocic
Keywords: پروتئین رتینوبلاستوما; Ang1/2; angiopoietin 1 or 2; BMPR2; Bone morphogenetic protein receptor type 2; CAV-1/2; caveolin-1/2; CHD; congenital heart disease; EC; endothelial cell; ECFC; endothelial colony forming cells; EGR-1; early growth response protein 1; EndoMT; endothelial
Keywords: پروتئین رتینوبلاستوما; 3-AP; 3-aminopyridine-2-carboxaldehyde thiosemicarbazone; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and Rad3-related protein; AMP/ADP/ATP; adenosine mono-, di-, and tri-phosphate; BLM; Bloom syndrome RecQ helicase-like; BRAF; V-raf mu
Keywords: پروتئین رتینوبلاستوما; α-TOS; α-tocopheryl succinate; BAP1; BRCA1 associated protein-1; BRCA1; breast cancer susceptibility gene 1; CDK4; cyclin-dependent kinase 4; CEA; carcinoembryonic antigen; CSC(s); cancer stem(-like) cell(s); CTGF; connective tissue growth factor (CCN2)
Keywords: پروتئین رتینوبلاستوما; ASK1; apoptosis signal-regulating kinase 1; ATF4; activating transcription factor 4; ATF6; activating transcription factor 6; Bcl-2; B-cell lymphoma 2; BiP; binding immunoglobulin protein; bZIP; basic leucine zipper; CDK; cyclin-dependent kinase; CDKI; CD
Keywords: پروتئین رتینوبلاستوما; BrdU; bromodeoxyuridine; Cdk; cyclin-dependent kinase; DAPI; 4â²,6-diamidino-2-phenylindole; DMEM; Dulbecco's modified eagle medium; Myo7a; myosin VIIA; P2; postnatal day 2; Pax2; paired box 2; pRb; retinoblastoma protein; Ptc; patched; Rb1; retinoblas
Keywords: پروتئین رتینوبلاستوما; APC/C; anaphase-promoting complex/cyclosome; BM; bone marrow; CDK; cyclin-dependent kinase; CKI; cyclin-dependent kinase inhibitor; CXCL12; chemokine (C-X-C motif) ligand 12; HSC; hematopoietic stem cell; Hsc70; heat shock cognate protein 70; LAP; latency
Functions and mechanisms of microRNA-31 in human cancers
Keywords: پروتئین رتینوبلاستوما; 3â²-UTRs3â²; -untranslated regions; ADC; Adenocarcinoma; BC; Breast cancer; BER; base excision repair; CDK4; cyclin-dependent kinase 4; CRC; Colorectal cancer; CRT; chemo-radiation therapy; C-TAD; COOH terminal transactivation domain; DHR1; dihydrorhoda
The reciprocal link between EVI1 and miRNAs in human malignancies
Keywords: پروتئین رتینوبلاستوما; EVI1; ecotropic virus integration site-1; MiR; microRNA; 3â²-UTR; 3â²-untranslated regions; AML; acute myeloid leukemia; DNA; deoxyribonucleic acid; RNA; ribonucleic acid; NF-κβ; nuclear factor kappa β; CHIP; Chromatin Immunoprecipitation; c-Myb; c-m
Repurposing of sodium valproate in colon cancer associated with diabetes mellitus: Role of HDAC inhibition
Keywords: پروتئین رتینوبلاستوما; ACF; aberrant crypt foci; ALP; alkaline phosphatase; ANOVA; one-way analysis of variance; CEA; carcinogenic embryonic antigen; DMH; 1,2 dimethylhydrazine; EDTA; ethylene diamine tetra acetic acid; ELISA; enzyme-linked immunosorbent assay; HbA1c; glycosyla
HBP1 phosphorylation by AKT regulates its transcriptional activity and glioblastoma cell proliferation
Keywords: پروتئین رتینوبلاستوما; DNMT1; DNA-methyltransferase 1; FOXO; Forkhead box O transcription factors; GST; glutathione S-transferase; HBP1; HMG-box protein 1; HEK; human embryonic kidney; HMG; high mobility group; HPLC; high performance liquid chromatography; KD; kinase dead; MS;
CCRK is a novel signalling hub exploitable in cancer immunotherapy
Keywords: پروتئین رتینوبلاستوما; 9G8; serine and arginine rich splicing factor 7; AKT; AKT serine/threonine kinase; AR; androgen receptor; ARE; androgen response element; ARG1; arginase 1; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and rad3-related protein; BMDC; mous
SIPS as a model to study age-related changes in proteolysis and aggregate formation
Keywords: پروتئین رتینوبلاستوما; AGEs; advanced glycation endproducts; ALP; autophagy-lysosomal pathway; ATM; ataxia teleangiectasia mutated; BrdU; bromodeoxyuridine; DDR; DNA damage response; DOX; doxorubicin; HDFs; Human diploid fibroblasts; H2O2; hydrogen peroxide; ICAM; intercellular
Aspartate beta-hydroxylase promotes cholangiocarcinoma progression by modulating RB1 phosphorylation
Keywords: پروتئین رتینوبلاستوما; Alpha-ketoglutarate; Cancer metabolism; IDH1 mutations; 2-Hydroxyglutarate; Bile duct tumors; CCA; Cholangiocarcinoma; ASPH; aspartate beta-hydroxylase; RB1; retinoblastoma protein; [(R)2-HG]; (R)2-hydroxyglutarate; DFO; deferoxamine mesylate salt; DMOG;
Mevalonate pathway blockage enhances the efficacy of mTOR inhibitors with the activation of retinoblastoma protein in renal cell carcinoma
Keywords: پروتئین رتینوبلاستوما; Mevalonate pathway; Statins; mTOR inhibitors; Retinoblastoma protein; Renal cell carcinoma;
Adipocytes spectrum - From homeostasia to obesity and its associated pathology
Keywords: پروتئین رتینوبلاستوما; Acrp30 (AdipoQ); adiponectin gene; AdipoR; adiponectin receptor; AGE; angiotensinogen; ALP; alkaline phosphatase; Ang II; angiotensin II; Angptl2; angiopoietin-like protein-2; Aqp7; aquaporin-7; aP2; adipocyte-specific fatty acid binding protein 2 gene; A
Mini-reviewThe role of the NORE1A tumor suppressor in Oncogene-Induced Senescence
Keywords: پروتئین رتینوبلاستوما; RASSF; HIPK2; PP1A; Retinoblastoma; p53; Ras; OIS; Oncogene-Induced Senescence; NORE1A; Novel Ras Effector 1A; Rb; Retinoblastoma Protein; PTM; Post-Translational Modification; EGFR; Epidermal Growth Factor Receptor; NF1; Neurofibromin 1; DAB2IP; DAB2 Int
Deregulation of hsa-miR-20b expression in TNF-α-induced premature senescence of human pulmonary microvascular endothelial cells
Keywords: پروتئین رتینوبلاستوما; RS; replicative senescence; CIPS; cytokine-induced premature senescence; pRB; retinoblastoma protein; TNF-α; tumor necrosis factor alpha; SA-β-gal; senescence-associated beta-galactosidase; HMVEC-Ls; human pulmonary microvascular endothelial cells; PD;
E2F6 protein levels modulate drug induced apoptosis in cardiomyocytes
Keywords: پروتئین رتینوبلاستوما; α-mhc; α-myosin heavy chain; β2-AR; beta-2-adrenergic receptor; Bax; Bcl2 associated protein X; Bcl2; B-cell lymphoma 2; Blm2; bloom syndrome 2 homolog; Bnip3; Bcl2 interacting protein 3; Chk1; checkpoint kinase 1; c-src; proto-oncogene tyrosine protei
CDK4/6 Inhibition as a therapeutic strategy in breast cancer: palbociclib, ribociclib, and abemaciclib
Keywords: پروتئین رتینوبلاستوما; Palbociclib; Ribociclib; Abemaciclib; CDK 4; CDK 6; CDK 4 inhibitors; CDK 6 inhibitors; CDK4/6 inhibitors; retinoblastoma; retinoblastoma protein; me-too cancer therapies; FDA approvals;
Combined Inhibition of CDK4/6 and PI3K/AKT/mTOR Pathways Induces a Synergistic Anti-Tumor Effect in Malignant Pleural Mesothelioma Cells
Keywords: پروتئین رتینوبلاستوما; MPM; Malignant Pleural Mesothelioma; BAP1; BRCA1 Associated Protein 1; CDK; Cyclin-dependent kinase; RB; Retinoblastoma Protein; SA-β-GAL; Senescence Associated β-Galactosidase;
ReviewCell Cycle Control by PTEN
Keywords: پروتئین رتینوبلاستوما; PTEN; phosphatase and tensin homolog; CIN; chromosome instability; CDK; cyclin-dependent Ser/Thr kinase; RB; retinoblastoma protein; SCF; Skp1/CUL1/F-box protein; APC/C; anaphase-promoting complex/cyclosome; CDH1; cdc20 homolog; PI3K; phosphoinositide 3-k
Degenerate cysteine patterns mediate two redox sensing mechanisms in the papillomavirus E7 oncoprotein
Keywords: پروتئین رتینوبلاستوما; CRD; cysteine richdomain; ROS; Reactive oxygen species; H2O2; hydrogen peroxide; NOXs; NADPH oxidases; SOD; superoxide dismutase; HPV; human papillomavirus; Rb; retinoblastoma protein; EK; enterokinase; ROIs; regions of interest; RT; retention time;
P53 tumor suppressor is required for efficient execution of the death program following treatment with a cytotoxic limonoid obtained from Melia azedarach
Keywords: پروتئین رتینوبلاستوما; Meliartenin; 12-Hydroxyamoorastatin; Cytotoxicity; Apoptosis; Cell cycle arrest; HCT116; p53; ALL; acute lymphoblastic leukemia; BrdU; 5-bromo-2'-deoxyuridine; CML; chronic myeloid leukemia; DMSO; dimethyl sulfoxide; DOX; doxorubicin; FBS; fetal bovine
Emerging differential roles of the pRb tumor suppressor in trichodysplasia spinulosa-associated polyomavirus and Merkel cell polyomavirus pathogeneses
Keywords: پروتئین رتینوبلاستوما; TSPyV; trichodysplasia spinulosa-associated polyomavirus; TS; trichodysplasia spinulosa; MCPyV; Merkel cell polyomavirus; MCC; Merkel cell carcinoma; sT antigen; small T antigen; LT antigen; large T antigen; pRb; retinoblastoma protein; PP2A; protein phos
Cyclin-Dependent Kinase 4/6 Inhibition for the Treatment of Unresectable Mature Teratoma: Long-Term Follow-Up of a Phase II Study
Keywords: پروتئین رتینوبلاستوما; Cell cycle; Cyclin-dependent kinases; Germ cell tumor; Palbociclib; Retinoblastoma protein;
Down-regulation of BNIP3 by olomoucine, a CDK inhibitor, reduces LPS- and NO-induced cell death in BV2 microglial cells
Keywords: پروتئین رتینوبلاستوما; Aβ; amyloid β; BH3; Bclâ2 homology domain 3; BNIP3; Bcl-2/adenovirus E1B 19âkDa-interacting protein 3; CNS; central nervous system; cPTIO; carboxy-PTIO; CDK; cyclin-dependent kinase; DMEM; Dulbecco's modified Eagle medium; HD; Huntington's disea
Rb selectively inhibits innate IFN-β production by enhancing deacetylation of IFN-β promoter through HDAC1 and HDAC8
Keywords: پروتئین رتینوبلاستوما; Retinoblastoma protein; Innate immunity; IFN-β; Histone deacetylase; Inflammation
The role of connexin43-Src interaction in astrocytomas: A molecular puzzle
Keywords: پروتئین رتینوبلاستوما; Cx43; connexin43; Cx43CT; C-terminal domain of connexin43; GLUT-3; glucose transporter-3; GSC; glioma stem cells; HIF; hypoxia-inducible factor; HK2; type II hexokinase; IDP; intrinsically disordered protein; IDR; intrinsically disordered region; MAPK; mi
The Interaction Mode of the Acidic Region of the Cell Cycle Transcription Factor DP1 with TFIIH
Keywords: پروتئین رتینوبلاستوما; DBD; DNA-binding domain; GAL4 DBD; DBD of GAL4; HSQC; heteronuclear single quantum coherence; LZ; leucine zipper; MB; marked box; TAD; transactivation domain; pRB; retinoblastoma protein; PH; pleckstrin homology; WT; wild-type; NOE; nuclear Overhauser eff
Roseotoxin B Improves Allergic Contact Dermatitis through a Unique Anti-Inflammatory Mechanism Involving Excessive Activation of Autophagy in Activated T Lymphocytes
Keywords: پروتئین رتینوبلاستوما; ACD; allergic contact dermatitis; CCCP; carbonyl cyanide m-chlorophenylhydrazone; ConA; concanavalin A; CQ; chloroquine; CsA; cyclosporine A; LC3; microtubule-associated protein 1 light chain 3; p27kip; cyclin-dependent kinase inhibitor p27; p-AKT; phosph
The elusive endogenous adipogenic PPARγ agonists: Lining up the suspects
Keywords: پروتئین رتینوبلاستوما; NO; nitric oxide; NO2; dioxide radical; O2; superoxide; ONO2â; Â peroxynitrite; 15-dPGJ2; 15-deoxy-Î12,14-prostaglandin J2; AA; arachidonic acid; ADH; alcohol dehydrogenase; AF-1; ligand-independent activation function; AF-2; ligand-dependent activatio
The inhibitory mechanism by curcumin on the Zac1-enhanced cyclin D1 expression in human keratinocytes
Keywords: پروتئین رتینوبلاستوما; Zac1; a zinc-finger protein which regulates cell cycle arrest and apoptosis 1; pRb; Retinoblastoma protein; CDKs; cyclin-dependent kinases; AP-1; activator protein-1; RLU; relative light units; ACTN; α-actinin; RT-PCR; reverse transcription- polymerase c
ANXA1Ac2-26 peptide reduces ID1 expression in cervical carcinoma cultures
Keywords: پروتئین رتینوبلاستوما; [LaCit2]3; lanthanum citrate complex; μg; microgram; ACTB; beta-actin; ANX; annexin; ANXA1; annexin A1; BMP4; bone morphogenetic protein 4; BMPR1B; bone morphogenetic protein receptor, type IB; cDNA; complementary DNA; CO2; carbon dioxide; DNA; deoxyribo
Inhibition of protein phosphatase-1 and -2A decreases the chemosensitivity of leukemic cells to chemotherapeutic drugs
Keywords: پروتئین رتینوبلاستوما; BSA; bovine serum albumin; CHAPS; 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate; CLA; calyculin A; CPI-17; C-kinase phosphatase-1 inhibitory protein of 17Â kDa; DMSO; dimethyl sulfoxide; DNR; daunorubicin; EDTA; ethylenediaminetetraacetic acid
Antiproliferative activity of the isoindigo 5â²-Br in HL-60 cells is mediated by apoptosis, dysregulation of mitochondrial functions and arresting cell cycle at G0/G1 phase
Keywords: پروتئین رتینوبلاستوما; Isoindigo; Anticancer; Apoptosis; Mitochondria dysfunction; Cell cycle; CDK; 5â²-Br; [(E)-1-(5â²-bromo-2â²-oxoindolin-3â²-ylidene)-6-ethyl-2,3,6,9-tetrahydro-2,9-dioxo-1H-pyrrolo[3,2-f]quinoline-8-carboxylic acid]; ÎΨm; difference in mitochondrial t
On the role of 4-hydroxynonenal in health and disease
Keywords: پروتئین رتینوبلاستوما; AD; Alzheimer's disease; ALDH; aldehyde dehydrogenase; AMI; acute myocardial infarction; ARE; antioxidant response element; CDK; cyclin-dependent kinase; CHF; chronic heart failure; DHLA; dihydrolipoic acid; ER; endoplasmic reticulum; GSH; glutathione; HL
Disruption of the mevalonate pathway induces dNTP depletion and DNA damage
Keywords: پروتئین رتینوبلاستوما; ACN; acetonitrile; BrdU; 5-bromo-2â²-deoxyuridine; DMAPP; dimethylallyl diphosphate; dNs; deoxyribonucleosides; dNTP; deoxyribonucleoside triphosphate; E2F; E2 transcription factor; Fmev; 6-fluoromevalonate; IPP; isopentenyl diphosphate; HU; hydroxyurea;
Design of a PROTAC that antagonizes and destroys the cancer-forming X-protein of the hepatitis B virus
Keywords: پروتئین رتینوبلاستوما; aa; amino acid; CPP; cell-penetrating peptide; HBV; hepatitis B virus; HCC; hepatocellular carcinoma; HIF; hypoxia-inducible factor; ODD; oxygen-dependent degradation; pRb; retinoblastoma protein; PROTAC; proteolysis targeting chimeric molecule; SCF; Skp1
Identification of a genetic interaction between the tumor suppressor EAF2 and the retinoblastoma protein (Rb) signaling pathway in C. elegans and prostate cancer cells
Keywords: پروتئین رتینوبلاستوما; The tumor suppressor EAF2; Retinoblastoma protein; lin-53; RNAi library screen; C. elegans; Apoptosis;
Promising roles of mammalian E2Fs in hepatocellular carcinoma
Keywords: پروتئین رتینوبلاستوما; E2Fs; E2F family of transcription factors; HCC; hepatocellular carcinoma; pRb; retinoblastoma protein; CDK; cyclin dependent kinase; DBD; DNA binding domain; DP; dimerization partner; LZ; leuzine zipper; MB; marked box; NLS; nuclear localization signal; C
HMGA2 induces transcription factor Slug expression to promote epithelial-to-mesenchymal transition and contributes to colon cancer progression
Keywords: پروتئین رتینوبلاستوما; ChIP; chromatin immunoprecipitation; DAPI; 4â²,6-diamidino-2-phenylindole dihydrochloride; EGF; epidermal growth factor; EMT; epithelial-to-mesenchymal transition; ERK1/2; extracellular signal-regulated kinase 1/2; FBS; fetal bovine serum; HMGA2; high mo
Decorin deficiency promotes hepatic carcinogenesis
Keywords: پروتئین رتینوبلاستوما; SLRP; small leucine-rich proteoglycan; RTK; receptor tyrosine kinase; TA; thioacetamide; DEN; diethyl nitrosamine; HCC; hepatocellular carcinoma; Dcnâ/â; decorin null; WT; wild type; p21WAF1/CIP1; cyclin-dependent kinase inhibitor p21; AP4; transcript
A new goniothalamin N-acylated aza-derivative strongly downregulates mediators of signaling transduction associated with pancreatic cancer aggressiveness
Keywords: پروتئین رتینوبلاستوما; Goniothalamin; N-acylated aza-derivatives; Pancreatic cancer; Panc-1 cells; AXL kinase; HIF-1α; GSH; glutathione; AXL; tyrosine-protein kinase receptor; ERK1/2; extracellular signal-regulated kinases 1 and 2; HIF-1α; hypoxia-inducible factor-1α; ROS;