Short-term transdermal estradiol enhances nitric oxide synthase III and estrogen receptor mRNA expression in arteries of women with coronary artery disease

After treatment with E2, NOS III, ER α, and ER β mRNA expression was enhanced in arterial vessels of postmenopausal women with CAD. NOS III mRNA expression was only correlated to ER α expression, suggesting that NOS III activation could be more mediated by ER α.